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Convection patterns gradients of non-living and living micro-entities in hydrogels

2020-12Journal article Restricted access
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dc.contributor.authorCanadas, Raphaël F.
dc.contributor.authorPatricio, Pedro
dc.contributor.authorBrancato, Virginia
dc.contributor.authorGasperini, Luca
dc.contributor.authorCaballero, David
dc.contributor.authorPires, Ricardo A.
dc.contributor.authorCosta, João
dc.contributor.authorPereira, Hélder
dc.contributor.authorYong, Ping
dc.contributor.authorda Silva, Lucília P.
dc.contributor.authorChen, Jie
dc.contributor.authorKundu, Subhas C.
dc.contributor.authorAraujo, Nuno
dc.contributor.authorReis, Rui L.
dc.contributor.authorMarques, AP
dc.contributor.authorOliveira, Joaquim M.
dc.date.accessioned2021-01-11T12:04:50Z
dc.date.available2021-01-11T12:04:50Z
dc.date.issued2020-12
dc.description.abstractInducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the common tissue fabrication methodologies often result in dissimilar interfaces, lacking continuity through the interfaced engineered tissues. Thus, there is an urgent need for the fabrication of heterotypic but continuous engineered tissues with spatial control over biomimetic features. Here, we demonstrate the influence of gel injection temperature on the patterning of gradients of non-living and living entities. The experimental part was confirmed by numerical modelling, showing the formation of convective lines which spatially drive microscale microparticle and cells when different temperatures are applied in the sequential injection of two gels. Based on this finding, pure gellan gum (GG) and blended GG with methacrylated gelatin (Ge1MA) systems were used to program the formation of gradient features in hydrogels, such as microparticle and cells distribution patterns, polymeric bioactivity, degradation, controlled release, and stiffness. The correlation between gel injection temperature and gradients formation can be applied to tissue interface modelling, regeneration, drug release systems, and broader materials engineering fields.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCANADAS, Rhafael F.; [et al] – Convection patterns gradients of non-living and living micro-entities in hydrogels. Applied Materials Today. ISSN 2352-9407. Vol. 21 (2020), pp. 1-18pt_PT
dc.identifier.doi10.1016/j.apmt.2020.100859pt_PT
dc.identifier.issn2352-9407
dc.identifier.urihttp://hdl.handle.net/10400.21/12598
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCEECIND/00352/2017 - FCTpt_PT
dc.relationNOVEL OSTEOCHONDRAL 3D MODEL AS AN IN VITRO TECHNOLOGICAL PLATFORM FOR DRUGS SCREENING: UNDERSTANDING THE MOLECULAR AND CELLULAR CHANGES DURING OSTEOARTHRITIS PROGRESSION
dc.relationIF/01285/2015 - FCTpt_PT
dc.relationPTDC/EMD-EMD/29139/2017 - Programa Operacional Competitividade e Internacionalizacao (POCI)pt_PT
dc.relationPTDC/EMD-EMD/29139/2017 - FCTpt_PT
dc.relation02/SAICT/2017 - FCTpt_PT
dc.relation028070 - FCTpt_PT
dc.relationM-ERA-NET/0001/2014 - FCTpt_PT
dc.relationPTDC/FIS-MAC/28146/2017 - FCT (LISBOA-01-0145-FEDER-028146)pt_PT
dc.relationUID/FIS/00618/2019 - FCTpt_PT
dc.relationPTDC/BTM-ORG/28168/2017 - FCT project BREAST-ITpt_PT
dc.relation2016/CON15/CAN6 - FLADpt_PT
dc.relation.publisherversionhttps://reader.elsevier.com/reader/sd/pii/S2352940720303073?token=18811AA538FBB0284A6A0AC2BF6A742FEF76EE100E868EF7622F5369F0482F81979252B3F632ED12B36E75219078DDA6pt_PT
dc.subjectGradient structurept_PT
dc.subjectThermal convectionpt_PT
dc.subjectTemperature patternspt_PT
dc.subjectSoft hydrogelspt_PT
dc.subjectTissue engineeringpt_PT
dc.titleConvection patterns gradients of non-living and living micro-entities in hydrogelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNOVEL OSTEOCHONDRAL 3D MODEL AS AN IN VITRO TECHNOLOGICAL PLATFORM FOR DRUGS SCREENING: UNDERSTANDING THE MOLECULAR AND CELLULAR CHANGES DURING OSTEOARTHRITIS PROGRESSION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F92565%2F2013/PT
oaire.citation.endPage18pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleApplied Materials Todaypt_PT
oaire.citation.volume21pt_PT
person.familyNameFaustino Canadas
person.familyNamePatricio
person.familyNameBrancato
person.familyNameGasperini
person.familyNameCaballero Vila
person.familyNamePires
person.familyNameCosta
person.familyNameCardoso Pereira
person.familyNameKundu
person.familyNameAraujo
person.familyNameReis
person.familyNameMarques
person.familyNameOliveira
person.givenNameRaphaël
person.givenNamePedro
person.givenNameVirginia
person.givenNameLuca
person.givenNameDavid
person.givenNameRicardo
person.givenNameJoão
person.givenNameHélder Ricardo
person.givenNameSubhas C.
person.givenNameNuno
person.givenNameRui L.
person.givenNameAlexandra
person.givenNameJoaquim Miguel
person.identifierRaphaël F. Canadas
person.identifierI-4571-2015
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person.identifier.scopus-author-id24467430000
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person.identifier.scopus-author-id56861715700
person.identifier.scopus-author-id22035647000
person.identifier.scopus-author-id25951486700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
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