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Herpesviruses serology distinguishes different subgroups of patients from the United Kingdom myalgic encephalomyelitis/chronic fatigue syndrome biobank

2021Journal article Open access
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dc.contributor.authorDomingues, Tiago Dias
dc.contributor.authorGrabowska, Anna D.
dc.contributor.authorLee, Ji-Sook
dc.contributor.authorAmeijeiras-Alonso, Jose
dc.contributor.authorWestermeier, Francisco
dc.contributor.authorScheibenbogen, Carmen
dc.contributor.authorCliff, Jacqueline M.
dc.contributor.authorNacul, Luis
dc.contributor.authorLacerda, Eliana M.
dc.contributor.authorMouriño, Helena
dc.contributor.authorSepulveda, Nuno
dc.date.accessioned2022-07-14T08:47:14Z
dc.date.available2022-07-14T08:47:14Z
dc.date.issued2021
dc.description.abstractThe evidence of an association between Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and chronic herpesviruses infections remains inconclusive. Two reasons for the lack of consistent evidence are the large heterogeneity of the patients’ population with different disease triggers and the use of arbitrary cutoffs for defining seropositivity. In this work we re-analyzed previously published serological data related to 7 herpesvirus antigens. Patients with ME/CFS were subdivided into four subgroups related to the disease triggers: S0-42 patients who did not know their disease trigger; S1-43 patients who reported a non-infection trigger; S2-93 patients who reported an infection trigger, but that infection was not confirmed by a lab test; and S3-48 patients who reported an infection trigger and that infection was confirmed by a lab test. In accordance with a sensitivity analysis, the data were compared to those from 99 healthy controls allowing the seropositivity cutoffs to vary within a wide range of possible values. We found a negative association between S1 and seropositivity to Epstein-Barr virus (VCA and EBNA1 antigens) and Varicella-Zoster virus using specific seropositivity cutoff. However, this association was not significant when controlling for multiple testing. We also found that S3 had a lower seroprevalence to the human cytomegalovirus when compared to healthy controls for all cutoffs used for seropositivity and after adjusting for multiple testing using the Benjamini-Hochberg procedure. However, this association did not reach statistical significance when using Benjamini-Yekutieli procedure. In summary, herpesviruses serology could distinguish subgroups of ME/CFS patients according to their disease trigger, but this finding could be eventually affected by the problem of multiple testing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDOMINGUES, Tiago Dias; [et al] – Herpesviruses serology distinguishes different subgroups of patients from the United Kingdom myalgic encephalomyelitis/chronic fatigue syndrome biobank. Frontiers in Medicine. ISSN 2296-858X. N.º 8 (2021), pp. 1-11.pt_PT
dc.identifier.doi10.3389/fmed.2021.686736pt_PT
dc.identifier.issn2296-858X
dc.identifier.urihttp://hdl.handle.net/10400.21/14832
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationProject MTM2016- 76969-P - Spanish State Research Agency (AEI)pt_PT
dc.relationCentre of Statistics and its Applications
dc.relationCenter for Mathematics, Fundamental Applications and Operations Research
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmed.2021.686736/fullpt_PT
dc.subjectDisease triggerpt_PT
dc.subjectCutoff valuept_PT
dc.subjectStratificationpt_PT
dc.subjectEpstein-Barr víruspt_PT
dc.subjectHuman cytomegaloviruspt_PT
dc.subjectVaricella-zoster víruspt_PT
dc.subjectHuman herpesvirus-6pt_PT
dc.subjectHerpes simplex virus 1 and 2pt_PT
dc.titleHerpesviruses serology distinguishes different subgroups of patients from the United Kingdom myalgic encephalomyelitis/chronic fatigue syndrome biobankpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardTitleCenter for Mathematics, Fundamental Applications and Operations Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04561%2F2020/PT
oaire.citation.endPage11pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Medicinept_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameDomingues
person.familyNameAmeijeiras-Alonso
person.familyNameWestermeier
person.familyNameScheibenbogen
person.familyNameNacul
person.familyNameMouriño Silva Nunes
person.familyNameSepulveda
person.givenNameTiago Miguel Dias
person.givenNameJose
person.givenNameFrancisco
person.givenNameCarmen
person.givenNameLuis
person.givenNameMaria Helena
person.givenNameNuno
person.identifier166395
person.identifier.ciencia-idE513-DD75-AD5C
person.identifier.ciencia-id551F-A4E0-1728
person.identifier.ciencia-idC11D-9BCF-43BF
person.identifier.orcid0000-0002-4034-4276
person.identifier.orcid0000-0002-4122-6992
person.identifier.orcid0000-0002-4476-4198
person.identifier.orcid0000-0002-8554-9638
person.identifier.orcid0000-0003-1411-8088
person.identifier.orcid0000-0001-7606-9643
person.identifier.orcid0000-0002-8542-1706
person.identifier.scopus-author-id57206260370
person.identifier.scopus-author-id57201518424
person.identifier.scopus-author-id35390203600
person.identifier.scopus-author-id6506171756
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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