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Cytotoxicity of filtering respiratory protective devices from the waste sorting industry: a comparative study between interior layer and exhalation valve

2021-10Journal article Open access
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dc.contributor.authorViegas, Carla
dc.contributor.authorTwarużek, Magdalena
dc.contributor.authorDias, Marta
dc.contributor.authorAlmeida, Beatriz
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorSoszczyńska, Ewelina
dc.contributor.authorViegas, Susana
dc.contributor.authorCaetano, Liliana Aranha
dc.date.accessioned2021-05-03T18:22:17Z
dc.date.available2024-05-03T00:30:19Z
dc.date.issued2021-10
dc.descriptionProject EXPOsE. Project nº 23222 (02/SAICT/2016).pt_PT
dc.descriptionProject Waste FRPD. Project IPL/2018/WasteFRPD_ESTeSL.pt_PT
dc.descriptionUIDB/05608/2020. UIDP/05608/2020.pt_PT
dc.description.abstractFiltering respiratory protection devices (FRPD) is mandatory for workers to wear in the Portuguese waste-sorting industry. Previous results regarding microbial contamination found on the FRPD interior layer raised the question of whether microbial contamination from the exhalation valve would also have cytotoxicity effects. Since the FRPD exhalation valves are very close to workers’ nose and mouth, they represent a source of exposure to bioburden by inhalation. This study aimed to evaluate the cytotoxicity of the microbial contamination present in the FRPD exhalation valves. For this purpose, the cytotoxicity effects were determined through the MTT assay in two different cell lines (human A549 epithelial lung cells, and swine kidney cells) and compared with previous results obtained with FRPD interior layers. The contamination present in the FRPD exhalation valves presented some cytotoxicity on epithelial lung cells, suggesting the inhalation route as a potential route of exposure through the use of FRPD in the waste-sorting industry. Half-maximal (50%) inhibitory concentration (IC50) values were lower for the FRPD interior layer than exhalation valves in lung cells, with overall cytotoxicity lower in exhalation valves when compared to the interior layer (z = −4.455, p = 0.000). Higher bacterial counts in TSA were correlated with lower IC50 values, thus, higher cytotoxicity effect in lung cells. No statistically significant differences were detected among different workplaces.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas C, Twarużek M, Dias M, Almeida B, Carolino E, Viegas S, Caetano LA, et al. Cytotoxicity of filtering respiratory protective devices from the waste sorting industry: a comparative study between interior layer and exhalation valve. Environ Int. 2021;155:106603.pt_PT
dc.identifier.doi10.1016/j.envint.2021.106603pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13271
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationProject EXPOsE. Project nº 23222 (02/SAICT/2016).pt_PT
dc.relationProject Waste FRPD. Project IPL/2018/WasteFRPD_ESTeSL.pt_PT
dc.relationHealth and Technology Research Center
dc.relationHealth and Technology Research Center
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0160412021002282?via%3Dihubpt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectCytotoxicitypt_PT
dc.subjectFiltering respiratory protective devicespt_PT
dc.subjectMTT assaypt_PT
dc.subjectPassive samplingpt_PT
dc.subjectWaste sorting environmentpt_PT
dc.subjectRisk assessmentpt_PT
dc.subjectProject EXPOsEpt_PT
dc.subjectProject nº 23222 (02/SAICT/2016)pt_PT
dc.subjectProject Waste FRPDpt_PT
dc.subjectProject IPL/2018/WasteFRPD_ESTeSLpt_PT
dc.subjectUIDB/05608/2020pt_PT
dc.subjectUIDP/05608/2020pt_PT
dc.titleCytotoxicity of filtering respiratory protective devices from the waste sorting industry: a comparative study between interior layer and exhalation valvept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth and Technology Research Center
oaire.awardTitleHealth and Technology Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05608%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05608%2F2020/PT
oaire.citation.startPage106603pt_PT
oaire.citation.titleEnvironment Internationalpt_PT
oaire.citation.volume155pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameViegas
person.familyNameCarolino
person.familyNameViegas
person.familyNameAranha Caetano
person.givenNameCarla
person.givenNameElisabete
person.givenNameSusana
person.givenNameLiliana
person.identifier248817
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.orcid0000-0002-1545-6479
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-1496-2609
person.identifier.ridB-7217-2013
person.identifier.ridF-1012-2015
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id55443609700
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35270591500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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