| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 3.33 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Os vírus, contrariamente a outras classes de agentes que afectam o organismo, não são observáveis em microscopia óptica, reflectindo-se apenas microscopicamente em efeitos citopáticos virais (ECPV), que permitem identificá-los por constituírem um conjunto de alterações patognomônicas a nível celular.
O aumento nuclear, a variação da morfologia celular, a perda do padrão da cromatina, as inclusões intranucleares ou intracitoplasmáticas ou a multinucleação, são alguns dos ECPV mais comuns. Entre os vírus que afectam a mucosa genital, na família Herpesviridae, inserem-se o Herpes Simplex 2 e o Citomegalovírus, cujo diagnóstico deverá ter em conta a complexidade dos mecanismos de replicação. Assim, e apesar dos vários métodos para a detecção do vírus, a citologia continua a ser um método viável para o diagnóstico destas infecções virais, sendo que a compreensão do processo de infecção contribui para a correcta avaliação microscópica. Este trabalho tem como finalidade efetuar uma revisão bibliográfica sobre o grupo Herpes, focando o Herpes Simplex 2 e Citomegalovírus; assim como, explicar e relacionar os ECPV, associados ao grupo Herpes, tendo por base os mecanismos de infecção.
ABSTRACT - In opposite to other external agents classes, which affect the organism, viruses are not observed in light microscopy, resulting in cytopathic viral effects (CPVE). Those are a group of cellular modifications related to certain microorganisms. The most common CPVE are nuclear increase, the variation of cellular morphology, loss of chromatin pattern, intranuclear or intracytoplasmatic inclusions, and multinucleation. The Herpesviridae family includes the Herpes Simplex 2 Virus and the Cytomegalovirus that affect the genital mucosa. The complex diagnostic of these viruses should considerate the replication mechanisms. In spite of several methods of virus detection, Cytology still is a viable way to diagnose these viral infections. The understanding of the infection process contributes to a correct microscopic evaluation. This revision hopes to remember the importance of the understanding of the replication mechanisms, which are correlated with CPVE, associated with the Herpesvirus group.
ABSTRACT - In opposite to other external agents classes, which affect the organism, viruses are not observed in light microscopy, resulting in cytopathic viral effects (CPVE). Those are a group of cellular modifications related to certain microorganisms. The most common CPVE are nuclear increase, the variation of cellular morphology, loss of chromatin pattern, intranuclear or intracytoplasmatic inclusions, and multinucleation. The Herpesviridae family includes the Herpes Simplex 2 Virus and the Cytomegalovirus that affect the genital mucosa. The complex diagnostic of these viruses should considerate the replication mechanisms. In spite of several methods of virus detection, Cytology still is a viable way to diagnose these viral infections. The understanding of the infection process contributes to a correct microscopic evaluation. This revision hopes to remember the importance of the understanding of the replication mechanisms, which are correlated with CPVE, associated with the Herpesvirus group.
Description
Keywords
Efeitos citopáticos virais Herpesviridae Herpes simplex 2 Citomegalovírus Citologia Cytopathic viral effects Herpes simplex 2 virus Cytomegalovirus Cytology
Citation
Batista A, Caeiro A, Mendonça P, Amaral I. Herpes simplex 2 e citomegalovírus: efeitos citopáticos vs. mecanismos de infecção. Rev Bras Anal Clin. 2010;42(4):265-7.