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Influence of strain rate on the mechanical behavior of dry and hydrated chitosan-based dense materials for bioabsorbable implant applications

2021-04Journal article Restricted access
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dc.contributor.authorFigueiredo, Lígia
dc.contributor.authorGregório, Afonso V. L.
dc.contributor.authorRodrigues, Alexandra
dc.contributor.authorRosa, P.A.R.
dc.date.accessioned2021-04-21T09:39:44Z
dc.date.available2021-04-21T09:39:44Z
dc.date.issued2021-04
dc.description.abstractChitosan has generated enormous interest in the scientific community because of its distinctive biological and physicochemical properties, which allow new advanced structures and applications. Porous chitosan scaffolds have been extensively studied and explored in bone generation, however it is still a challenge to obtain bio-absorbable orthopedic implants that involves pure 3D dense chitosan geometries due to the inherent difficulties in producing and shaping such structures. In this work, chitosan was blended with 10% glycerol and 10% glycerol + 10% biphasic mixture of calcium phosphate (70% hydroxyapatite with 30% beta-tricalcium phosphate) to produce dense chitosan-based blocks, which were then shaped into rods. The introduction of plasticizer aimed to improve the materials ductility while the ceramic particles were used to increase stiffness and strength. The mechanical behavior of the two chitosan-based compositions was evaluated by uniaxial compression tests using a customized split-Hopkinson pressure bar (SHPB). The specimens were analysed in quasi-static conditions (less than 0.1 s(-1)) and medium strain rate conditions (200-800 s(-1)), both in dry state and in different hydrated conditions, in the latter case to approximate the in vivo implant conditions. The results showed promising results for the intended application. The chitosan blends present excellent ductility with an elastic perfect-plastic behavior in quasi-static conditions, with yield stresses around 40 MPa for the dry state, with a decay for 3 MPa after 48h hydration. An empirical model was proposed to describe the flow stress curves, with a good agreement with the experimental data, allowing future modelling of this material behavior.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFIGUEIREDO, Lígia; [et al] – Influence of strain rate on the mechanical behavior of dry and hydrated chitosan-based dense materials for bioabsorbable implant applications. Journal of the Mechanical Behavior of Biomedical Materials. ISSN 1751-6161. Vol. 116 (2021), pp. 1-10pt_PT
dc.identifier.doi10.1016/j.jmbbm.2021.104337pt_PT
dc.identifier.eissn1878-0180
dc.identifier.issn1751-6161
dc.identifier.urihttp://hdl.handle.net/10400.21/13218
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUIDB/50022/2020 - FCT, through IDMEC, under LAETApt_PT
dc.relation.publisherversionhttps://reader.elsevier.com/reader/sd/pii/S1751616121000291?token=5AC81B3CBA52F0706AF55811FF58C2D4DA1C8A9D6D587549EC6254B617A4D292642FEA116CB8C94975F96CFE24C8ABD0&originRegion=eu-west-1&originCreation=20210421092928pt_PT
dc.subjectChitosanpt_PT
dc.subjectImplantspt_PT
dc.subjectMechanical testingpt_PT
dc.subjectHydrationpt_PT
dc.subjectStresspt_PT
dc.subjectStrain ratept_PT
dc.titleInfluence of strain rate on the mechanical behavior of dry and hydrated chitosan-based dense materials for bioabsorbable implant applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F51949%2F2012/PT
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of the Mechanical Behavior of Biomedical Materialspt_PT
oaire.citation.volume116pt_PT
oaire.fundingStreamSFRH
person.familyNameFigueiredo
person.familyNameRodrigues
person.familyNameRosa
person.givenNameLígia
person.givenNameAlexandra
person.givenNamePedro
person.identifier.ciencia-idCC1C-2AC7-105E
person.identifier.ciencia-id951B-7AC1-277E
person.identifier.ciencia-id3D1B-EF0C-C6BF
person.identifier.orcid0000-0002-5150-3682
person.identifier.orcid0000-0001-9446-9384
person.identifier.orcid0000-0002-3363-0151
person.identifier.ridI-4763-2015
person.identifier.ridH-9160-2013
person.identifier.scopus-author-id55509454600
person.identifier.scopus-author-id35611047900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication77d34127-29c8-40f8-a17c-034b42833ca0
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relation.isAuthorOfPublication.latestForDiscovery2463345d-347a-4d3e-b9af-b4c561aacb1f
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