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Protection against malaria in heterozygous girls for G6PD deficiency in Angola

2019-11Conference object Open access
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dc.contributor.authorBrito, Miguel
dc.contributor.authorTchonhi, Chissengo
dc.date.accessioned2021-05-15T23:01:09Z
dc.date.available2021-05-15T23:01:09Z
dc.date.issued2019-11
dc.description.abstractG6PD deficiency has become more prevalent in malaria-endemic regions because genetic variants can confer protection against Plasmodium. However, these conclusions are still in debate. The aim of this work is to evaluate the prevalence of G6PD deficiency in an African holoendemic region for Plasmodium falciparum, estimating the genotype and phenotype of the enzyme, and evaluating the risk of malaria associated with the G6PD genotype. A prospective longitudinal cohort study, involving 1692 children selected in the maternity ward and monitored over quarterly medical consultations for two years. The G202A and A376G genotypes were determined through Real-Time PCR methods. For enzyme activity, we applied the NeoLISA kit for Neonatal G6PD deficiency screening to measure the NADPH produced calorimetrically in the kinetic model. The prevalence of the A-allele was 19.4%, with 19% hemizygous boys and 4.5% A-homozygous girls. Enzyme deficiency, measured by enzyme activity, was highly prevalent (32.7% in males and 30.5% in females). The average enzymatic activity was also low for A-hemizygous boys (1.66U/gHb) and for homozygous girls (0. 97U/gHb). Heterozygous girls would seem to hold some protection against malaria when compared to the other genotypes, mainly A-/A- (X2=14.35, p=0.014). The prevalence of G6PD deficiency among children in Bengo is high. Heterozygous girls, as proposed elsewhere, maybe the driving force for positive selection. This data may serve the ministry of health in taking safe and appropriate decisions regarding the usage of potentially unsafe drugs for G6PD deficient individuals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBrito M, Tchonhi C. Protection against malaria in heterozygous girls for G6PD deficiency in Angola. Am J Trop Med. 2019;101(Suppl 5):299.pt_PT
dc.identifier.doi10.4269/ajtmh.abstract2019pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13354
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://erj.ersjournals.com/content/54/suppl_63/PA2738pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectG6PD deficiencypt_PT
dc.subjectMalariapt_PT
dc.subjectGirlpt_PT
dc.subjectAngolapt_PT
dc.subjectProvíncia do Bengopt_PT
dc.titleProtection against malaria in heterozygous girls for G6PD deficiency in Angolapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage299pt_PT
oaire.citation.issueSuppl. 5pt_PT
oaire.citation.startPage299pt_PT
oaire.citation.titleAmerican Journal of Tropical Medicine and Hygienept_PT
oaire.citation.volume101pt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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