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Cilia distal domain: diversity in evolutionarily conserved structures

2019-02Journal article Open access
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dc.contributor.authorSoares, Helena
dc.contributor.authorCarmona, Bruno
dc.contributor.authorNolasco, Sofia
dc.contributor.authorMelo, Luís Viseu
dc.contributor.authorGonçalves, João
dc.date.accessioned2019-02-18T15:54:35Z
dc.date.available2019-02-18T15:54:35Z
dc.date.issued2019-02
dc.descriptionFCT_UID/Multi/00612; IPL/2016/TBCCentro_ESTeSL; IPL/2017/CILIOPAT_ESTeSL.pt_PT
dc.description.abstractEukaryotic cilia are microtubule-based organelles that protrude from the cell surface to fulfill sensory and motility functions. Their basic structure consists of an axoneme templated by a centriole/basal body. Striking differences in ciliary ultra-structures can be found at the ciliary base, the axoneme and the tip, not only throughout the eukaryotic tree of life, but within a single organism. Defects in cilia biogenesis and function are at the origin of human ciliopathies. This structural/functional diversity and its relationship with the etiology of these diseases is poorly understood. Some of the important events in cilia function occur at their distal domain, including cilia assembly/disassembly, IFT (intraflagellar transport) complexes' remodeling, and signal detection/transduction. How axonemal microtubules end at this domain varies with distinct cilia types, originating different tip architectures. Additionally, they show a high degree of dynamic behavior and are able to respond to different stimuli. The existence of microtubule-capping structures (caps) in certain types of cilia contributes to this diversity. It has been proposed that caps play a role in axoneme length control and stabilization, but their roles are still poorly understood. Here, we review the current knowledge on cilia structure diversity with a focus on the cilia distal domain and caps and discuss how they affect cilia structure and function.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSoares H, Carmona B, Nolasco S, Melo LV, Gonçalves J. Cilia distal domain: diversity in evolutionarily conserved structures. Cells. 2019;8(2):160.pt_PT
dc.identifier.doi10.3390/cells8020160pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/9520
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationIPL/2016/TBCCentro_ESTeSLpt_PT
dc.relationIPL/2017/CILIOPAT_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2073-4409/8/2/160pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCiliapt_PT
dc.subjectCilia distal domainpt_PT
dc.subjectMicrotubule-capping structurespt_PT
dc.subjectCilia structural diversitypt_PT
dc.subjectFCT_UID/Multi/00612pt_PT
dc.subjectIPL/2016/TBCCentro_ESTeSLpt_PT
dc.subjectIPL/2017/CILIOPAT_ESTeSLpt_PT
dc.titleCilia distal domain: diversity in evolutionarily conserved structurespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00612%2F2013/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage160pt_PT
oaire.citation.titleCellspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication718254be-c925-40e1-befc-ef8ab5913a8e
relation.isProjectOfPublication.latestForDiscovery718254be-c925-40e1-befc-ef8ab5913a8e

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