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Body composition, muscle strength, functional capacity, and physical disability risk in liver transplanted familial amyloidotic polyneuropathy patients

2011-07Journal article Open access
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dc.contributor.authorTomás, Maria Teresa
dc.contributor.authorSanta-Clara, Helena
dc.contributor.authorMonteiro, Estela
dc.contributor.authorBaynard, Tracy
dc.contributor.authorCarnero, Elvis
dc.contributor.authorBruno, Paula Marta
dc.contributor.authorBarroso, Eduardo
dc.contributor.authorSardinha, Luís
dc.contributor.authorFernhall, Bo
dc.date.accessioned2011-11-08T12:29:26Z
dc.date.available2011-11-08T12:29:26Z
dc.date.issued2011-07
dc.description.abstractAbstract: Background: Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease leading to sensory and motor polyneuropathies, and functional limitations. Liver transplantation is the only treatment for FAP, requiring medication that negatively affects bone and muscle metabolism. The aim of this study was to compare body composition, levels of specific strength, level of physical disability risk, and functional capacity of transplanted FAP patients (FAPTx) with a group of healthy individuals (CON). Methods: A group of patients with 48 FAPTx (28 men, 20 women) was compared with 24 CON individuals (14 men, 10 women). Body composition was assessed by dual-energy X-ray absorptiometry, and total skeletal muscle mass (TBSMM) and skeletal muscle index (SMI) were calculated. Handgrip strength was measured for both hands as was isometric strength of quadriceps. Muscle quality (MQ) was ascertained by the ratio of strength to muscle mass. Functional capacity was assessed by the six-minute walk test. Results: Patients with FAPTx had significantly lower functional capacity, weight, body mass index, total fat mass, TBSMM, SMI, lean mass, muscle strength, MQ, and bone mineral density. Conclusion: Patients with FAPTx appear to be at particularly high risk of functional disability, suggesting an important role for an early and appropriately designed rehabilitation program.por
dc.identifier.citationTomás MT, Santa-Clara H, Monteiro E, Baynard T, Carnero E, Bruno PM, Barroso E, Sardinha L, Fernhall B. Body composition, muscle strength, functional capacity, and physical disability risk in liver transplanted familial amyloidotic polyneuropathy patients. Clin Transplant. 2011;25(4):E406-14.por
dc.identifier.issn1399-0012
dc.identifier.urihttp://hdl.handle.net/10400.21/275
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherJohn Wiley & Sonspor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/j.1399-0012.2011.01436.x/abstractpor
dc.subjectFisioterapiapor
dc.subjectReabilitaçãopor
dc.subjectPolineuropatia amiloidótica familiarpor
dc.subjectTransplante de órgãospor
dc.subjectFígadopor
dc.subjectIncapacidade físicapor
dc.subjectSix-minute Walk Testpor
dc.subjectMassa muscularpor
dc.titleBody composition, muscle strength, functional capacity, and physical disability risk in liver transplanted familial amyloidotic polyneuropathy patientspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageE414por
oaire.citation.startPageE406por
oaire.citation.titleClinical Transplantationpor
person.familyNameTomás
person.givenNameMaria Teresa
person.identifier438585
person.identifier.ciencia-id3010-19D6-C7A5
person.identifier.orcid0000-0003-0491-8903
person.identifier.ridN-1940-2013
person.identifier.scopus-author-id36700434200
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication64ad74a4-4cd4-426e-a1ee-2ec846fdc6dd
relation.isAuthorOfPublication.latestForDiscovery64ad74a4-4cd4-426e-a1ee-2ec846fdc6dd

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