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Authors
Abstract(s)
A manufatura aditiva é considerada uma das tecnologias emergentes mais importantes dos últimos 10 anos. Entre as diferentes tecnologias de impressão 3D disponíveis, a estereolitografia (SLA) permite imprimir peças altamente detalhadas, num processo camada a camada, resultando numa eficiência avançada e num preço de produção mais baixo. A cura é feita por radiação ultravioleta, o que permite a produção de materiais biocompatíveis que não podem ser expostos a altas temperaturas. Esta área representa uma nova possibilidade para a produção de materiais híbridos, que combinam polímeros com agentes farmacêuticos ativos. Além disso, a utilização de polímeros e a tecnologia de impressão 3D promovem a sustentabilidade e a personalização dos tratamentos médicos, representando uma contribuição importante para a área da saúde. Neste contexto, o presente estudo teve como objetivo a potencial utilização de uma resina fotossensível, e uma mistura de polietilenoglicol e polietilenoglicol diacrilato como candidatos para produzir filmes e peças impressas em 3D, dopadas com diferentes fármacos (paracetamol, ibuprofeno e nimesulida) a fim de apresentarem possíveis propriedades anti-inflamatórias. Os filmes foram produzidos com cura a 405 nm e as peças 3D foram produzidas utilizando a técnica de SLA. Os materiais híbridos foram caracterizados química e mecanicamente, através da análise de FTIR-ATR, absorção de água e ensaios de tração, e os perfis de libertação foram registados em etanol, durante 48 horas, por espetrofotometria de UV-vis. Na generalidade, os materiais híbridos produzidos com polietilenoglicol e polietilenoglicol diacrilato apresentaram maiores taxas de libertação dos fármacos revelando-se mais promissores para possíveis aplicações biomédicas.
ABSTRACT - Additive manufacturing is considered one of the most important emerging technologies in the last 10 years. Among the different 3D printing technologies available, stereolithography (SLA) allows to printing of highly detailed pieces, in a layer-by-layer process resulting in advanced efficiency and lower production price. The cure is provided by ultraviolet radiation which allows the production of biocompatible materials that cannot be exposed to high temperatures. This field represents a new possibility for the production of hybrid materials, which combine polymers with active pharmaceutical ingredients. In addition, the use of polymers and 3D printing technology promotes the sustainability and personalization of medical treatments, representing an important contribution to the health field. In this context, reports the potential use of a photosensitive resin and the mixture of polyethylene glycol and polyethylene glycol diacrylate as good candidates for the production of film and 3D print pieces, doped with different drugs (acetaminophen, ibuprofen, and nimesulide) to present possible anti-inflammatory properties. Films were cured at 405 nm and 3D pieces were produced using the stereolithography technique. Hybrid materials were chemically and mechanically characterized, through FTIR ATR spectroscopy, water absorption, and tensile tests. and the dissolution profiles were recorded in ethanol, for 48h, spectrophotometrically. In general, the hybrid materials produced with polyethylene glycol and polyethylene glycol diacrylate showed higher drug release rates and were more promising for possible biomedical applications.
ABSTRACT - Additive manufacturing is considered one of the most important emerging technologies in the last 10 years. Among the different 3D printing technologies available, stereolithography (SLA) allows to printing of highly detailed pieces, in a layer-by-layer process resulting in advanced efficiency and lower production price. The cure is provided by ultraviolet radiation which allows the production of biocompatible materials that cannot be exposed to high temperatures. This field represents a new possibility for the production of hybrid materials, which combine polymers with active pharmaceutical ingredients. In addition, the use of polymers and 3D printing technology promotes the sustainability and personalization of medical treatments, representing an important contribution to the health field. In this context, reports the potential use of a photosensitive resin and the mixture of polyethylene glycol and polyethylene glycol diacrylate as good candidates for the production of film and 3D print pieces, doped with different drugs (acetaminophen, ibuprofen, and nimesulide) to present possible anti-inflammatory properties. Films were cured at 405 nm and 3D pieces were produced using the stereolithography technique. Hybrid materials were chemically and mechanically characterized, through FTIR ATR spectroscopy, water absorption, and tensile tests. and the dissolution profiles were recorded in ethanol, for 48h, spectrophotometrically. In general, the hybrid materials produced with polyethylene glycol and polyethylene glycol diacrylate showed higher drug release rates and were more promising for possible biomedical applications.
Description
Mestrado em Engenharia Biomédica
Keywords
Citation
Baptista IF. Impressão 3D de estruturas híbridas de base polimérica para libertação controlada de compostos anti-inflamatórios [dissertation]. Lisboa: Escola Superior de Tecnologia da Saúde de Lisboa – Instituto Superior de Engenharia de Lisboa/Instituto Politécnico de Lisboa; 2023.
Publisher
Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa