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Unsuccessful treatment in pulmonary tuberculosis: factors and a consequent predictive model

2018-04Journal article Restricted access
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dc.contributor.authorCosta-Veiga, Ana
dc.contributor.authorBriz, Teodoro
dc.contributor.authorNunes, Carla
dc.date.accessioned2017-11-06T15:59:03Z
dc.date.available2017-11-06T15:59:03Z
dc.date.issued2018-04
dc.description.abstractBackground - Cure is particularly valuable in pulmonary cases (PTB), as unsuccessful treatment fuels incidence and resistance to antibiotics. This study aims to identify individual factors of PTB unsuccessful treatment in Portugal and to develop a consequent predictive model. Methods: Using the Portuguese TB surveillance database (SVIG-TB), PTB cases older than 15 years notified from 2000 to 2012 in Continental Portugal were analyzed. Unsuccessful treatment included the WHO categories (failure, default, death and transferred out). Based on a literature review, predictors involved sociodemographic, behavioral, disease-related and treatment-related factors. Binary logistic regression was used to estimate unsuccessful treatment factors and to develop the predictive risk model. Results - The unsuccessful outcome rate in PTB patients was 11.9%. The predictive model included the following factors: TB/HIV co-infection (OR 4.93), age over 64 years (OR 4.37), IV drugs abuse (OR 2.29), other diseases (excluding HIV and Diabetes, OR 2.09) and retreatment (OR 1.44), displaying a rather good validity. Conclusion - The overall treatment unsuccessful treatment rate in PTB patients complies with the 85% WHO success threshold. The predictive model of unsuccessful treatment proved well. Nomogram representation allows an early, intuitive identification of PTB patients at increased risk. The model is liable to widespread use as a prognostic tool.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta-Veiga A, Briz T, Nunes C. Unsuccessful treatment in pulmonary tuberculosis: factors and a consequent predictive model. Eur J Public Health. 2018;28(2):252-8.pt_PT
dc.identifier.doi10.1093/eurpub/ckx136pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7459
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://academic.oup.com/eurpub/article/28/2/352/4317401pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPharmacypt_PT
dc.subjectPharmacologypt_PT
dc.subjectPublic healthpt_PT
dc.subjectPulmonary tuberculosispt_PT
dc.subjectHIVpt_PT
dc.subjectDiabetes mellituspt_PT
dc.subjectAntibiotic resistance, bacterialpt_PT
dc.subjectRetreatmentspt_PT
dc.subjectPatient prognosispt_PT
dc.subjectNomogrampt_PT
dc.subjectCoinfectionpt_PT
dc.subjectPortugalpt_PT
dc.titleUnsuccessful treatment in pulmonary tuberculosis: factors and a consequent predictive modelpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage258pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage252pt_PT
oaire.citation.titleEuropean Journal of Public Healthpt_PT
oaire.citation.volume28pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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