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Effects of an exercise training program in physical condition after liver transplantation in familial amyloidotic polyneuropathy: a case report

2011-01Journal article Open access
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dc.contributor.authorTomás, Maria Teresa
dc.contributor.authorSanta-Clara, Helena
dc.contributor.authorMonteiro, Estela
dc.contributor.authorBarroso, Eduardo
dc.contributor.authorSardinha, Luís
dc.date.accessioned2011-11-08T14:26:04Z
dc.date.available2011-11-08T14:26:04Z
dc.date.issued2011-01
dc.description.abstractIntroduction: Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease that leads to sensory and motor polyneuropathies as well as functional limitations. So far, liver transplantation is the only treatment for FAP because the mutated protein causing the disease is mainly produced in the liver. With the increasing survival of transplant recipients, functional and cardiovascular problems as consequences of immunosuppressant side effects are increasing associated with sedentary lifestyles and/or retransplantation status. We sought to analyze the impact of exercise training programs on 1 FAP patient’s course long-term after liver transplantation. Methodology. A FAP patient (female; 49 years of age; body mass index 18.8 kg/m2) underwent a liver transplantation 133 months before assessment. She was assessed for body composition, isometric quadriceps muscle strength, functional capacity, fatigue, and levels of physical activity before and after a 6-month period of combined exercise training. Results: After the exercise training program, almost all variables were improved, namely, total body skeletal muscle mass, proximal femoral bone mineral density, quadriceps strength, maximal oxygen consumption on 6 minutes walk test (6mwt) or VO2peak, total ventilation on 6mwt, and fatigue. The improvement in distance on 6mwt (69.2 m) was clinically significant. Preintervention the levels of physical activity were below international recommendations for health; after the program they achieved the recommendations. Conclusion: The results showed an improvement in functional capacity with a decrease in future disability risk associated with a better lifestyle with respect to physical activity levels in 1 patient.por
dc.identifier.citationTomás MT, Santa-Clara H, Monteiro E, Barroso E, Sardinha L. Effects of an exercise training program in physical condition after liver transplantation in familial amyloidotic polyneuropathy: a case report. Transplant Proc. 2011;43(1):257-8.por
dc.identifier.issn1873-2623
dc.identifier.urihttp://hdl.handle.net/10400.21/278
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0041134510019408por
dc.subjectFisioterapiapor
dc.subjectReabilitaçãopor
dc.subjectPolineuropatia amiloidótica familiarpor
dc.subjectTransplante de órgãospor
dc.subjectFígadopor
dc.titleEffects of an exercise training program in physical condition after liver transplantation in familial amyloidotic polyneuropathy: a case reportpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage258por
oaire.citation.startPage257por
oaire.citation.titleTransplantation Proceedingspor
person.familyNameTomás
person.givenNameMaria Teresa
person.identifier438585
person.identifier.ciencia-id3010-19D6-C7A5
person.identifier.orcid0000-0003-0491-8903
person.identifier.ridN-1940-2013
person.identifier.scopus-author-id36700434200
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication64ad74a4-4cd4-426e-a1ee-2ec846fdc6dd
relation.isAuthorOfPublication.latestForDiscovery64ad74a4-4cd4-426e-a1ee-2ec846fdc6dd

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