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Biomonitorization in hospital settings with cytostatics occupational exposure

2014-09Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, M. C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-10-14T12:16:08Z
dc.date.available2014-10-14T12:16:08Z
dc.date.issued2014-09
dc.description.abstractExposure in a hospital setting is normally due to the use of several antineoplastic drugs simultaneously. Nevertheless, the effects of such mixtures at the cell level and on human health in general are unpredictable and unique due to differences in practice of hospital oncology departments, in the number of patients, protection devices available, and the experience and safety procedures of medical staff. Health care workers who prepare or administer hazardous drugs or who work in areas where these drugs are used may be exposed to these agents in the air, on work surfaces, contaminated clothing, medical equipment, patient excreta, and other surfaces. These workers include specially pharmacists, pharmacy technicians, and nursing personnel. Exposures may occur through inhalation resulting from aerosolization of powder or liquid during reconstitution and spillage taking place while preparing or administering to patients, through Cytokinesis-block micronucleus test (CBMN) is extensively used in biomonitoring, since it determines several biomarkers of genotoxicity, such as micronuclei (MN), which are biomarkers of chromosomes breakage or loss, nucleoplasmic bridges (NPB), common biomarkers of chromosome rearrangement, poor repair and/or telomeres fusion, and nuclear buds (NBUD), biomarkers of elimination of amplified DNA.por
dc.description.sponsorshipAutoridade para as Condições de Trabalhopor
dc.identifier.citationLadeira C, Viegas S, Carolino E, Gomes MC, Brito M. Biomonitorization in hospital settings with cytostatics occupational exposure. In 3rd International Congress in Environmental Health – ICEH 2014, Porto (Portugal), 24-26 September 2014.por
dc.identifier.urihttp://hdl.handle.net/10400.21/3866
dc.language.isoengpor
dc.peerreviewedyespor
dc.relationProjecto 036APJ/09por
dc.relation.publisherversionhttp://www.iceh2014.pt.to/por
dc.subjectCytostatic drugspor
dc.subjectBiomonitoringpor
dc.subjectOccupational exposurepor
dc.subjectGenotoxicity biomarkerspor
dc.subjectHospitalpor
dc.titleBiomonitorization in hospital settings with cytostatics occupational exposurepor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopor
person.familyNameLadeira
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
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person.identifier.orcid0000-0001-5588-0074
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person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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