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Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response

2020-12Journal article Restricted access
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dc.contributor.authorCabral, Francisco
dc.contributor.authorCruz, A.
dc.contributor.authorCasaca, R.
dc.contributor.authorMonteiro, C.
dc.contributor.authorRamos, P.
dc.contributor.authorPedro, C.
dc.contributor.authorBrandão, F.
dc.contributor.authorFonseca, R.
dc.contributor.authorRatão, P.
dc.contributor.authorSaldado, L.
dc.contributor.authorPinto, Iola
dc.contributor.authorAbecasis, N.
dc.date.accessioned2021-01-05T15:17:37Z
dc.date.available2021-01-05T15:17:37Z
dc.date.issued2020-12
dc.description.abstractPurpose. - Neoadjuvant chemoradiotherapy (nCRT) followed by surgery in patients with resectable esophageal or esophagogastric junctional (GEJ) (Siewert I) cancer is associated with long term overall survival benefits. Up to one third of all patients submitted to nCRT present pathological complete response (pCR). F-18-fluorodeoxyglucose positron emission tomography with CT (F-18-FDG PET-CT) is an important tool for assessing treatment response. Purpose was to assess retrospectively the power of F-18-FDG PET-CT in predicting pCR to evaluate the feasibility of a "watch and wait" approach. Patients and methods. - Retrospective analysis of a prospective database with esophageal or GEJ submitted to pre-operative chemoradiation. Pre and pos treatment F-18-FDG PET-CT were reviewed and classified using visual assessment and PERCIST criteria and the values of maximum standard uptake value were also recorded. Patients were classified as pCR or non-PCR. F-18-FDG PET-CT and pathological findings were compared against each other. Results. - Forty-three patients were included. The median age was 67 years and 90.7% were male. All patients underwent preoperative CRT and were evaluated with F-18-FDG PET-CT pre and post treatment. Transthoracic surgery was performed in all patients. Histological type was adenocarcinoma in 37% and squamous cell carcinoma in 58%. pCR was achieved in 56% of cases. Visual assessment of F-18-FDG PET-CT showed overall sensitivity 57.9%, specificity 62.5% and PERCIST criteria had 100% sensibility and 16.7% specificity. Conclusions. - F-18-FDG PET-CT is not an ideal predictor of pCR but if we use the PERCIST criteria we will have a high sensitivity and negative predictive value, avoiding false negative scans. (C) 2020 Societe francaise de radiotherapie oncologique (SFRO).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCABRAL, F.; [et al] – Complete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic response. Cancer Radiotherapie. ISSN 1278-3218. Vol. 24, N.º 8 (2020), pp. 834-841pt_PT
dc.identifier.doi10.1016/j.canrad.2020.05.013pt_PT
dc.identifier.issn1278-3218
dc.identifier.issn1769-6658
dc.identifier.urihttp://hdl.handle.net/10400.21/12551
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://reader.elsevier.com/reader/sd/pii/S1278321820302869?token=BBD9D285B185A1717954ADA7D6622BA22FF39EB3D7E18758B14AAE14FCDCC1F57A6039684858CE10B555B209CEA6CF93pt_PT
dc.subjectEsophageal cancerpt_PT
dc.subjectNeoadjuvant chemoradiotherapypt_PT
dc.subjectF-18-FDG PET-CTpt_PT
dc.subjectPathological complete responsept_PT
dc.subjectWatch and waitpt_PT
dc.titleComplete pathological response (pCR) in gastroesophageal cancer: Correlation with metabolic responsept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage841pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage834pt_PT
oaire.citation.titleCancer Radiotherapiept_PT
oaire.citation.volume24pt_PT
person.familyNameCabral
person.familyNamePinto
person.givenNameFrancisco
person.givenNameIola
person.identifierR-000-ME5
person.identifier.ciencia-id5715-2B2D-9ADC
person.identifier.orcid0000-0003-2992-7822
person.identifier.orcid0000-0002-2945-1441
person.identifier.scopus-author-id34969436900
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8e7bf490-0891-4c48-9678-c2cfb97b1ecc
relation.isAuthorOfPublication137d7dcc-401e-4d4a-862f-1d955c6f7257
relation.isAuthorOfPublication.latestForDiscovery137d7dcc-401e-4d4a-862f-1d955c6f7257

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