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Longitudinal changes in crystalline lens thickness and power in children aged 6-12 years old

dc.contributor.authorHashemi, Hassan
dc.contributor.authorKhabazkhoob, Mehdi
dc.contributor.authorAzizi, Elham
dc.contributor.authorIribarren, Rafael
dc.contributor.authorLança, Carla
dc.contributor.authorGrzybowski, Andrzej
dc.contributor.authorRozema, Jos J.
dc.contributor.authorEmamian, Mohammad Hassan
dc.contributor.authorFotouhi, Akbar
dc.date.accessioned2023-12-21T18:29:36Z
dc.date.embargo2025-12-15
dc.date.issued2024-05
dc.descriptionThis work was supported by the Noor Ophthalmology Research Center and Shahroud University of Medical Sciences (Grant Number: 9329, 960351).pt_PT
dc.description.abstractObjectives: To determine the three-year changes in crystalline lens power (LP) and thickness (LT) in children and their associated factors. Methods: Schoolchildren aged 6-12 years living in Shahroud, northeast Iran were examined in 2015 and 2018. The Bennett formula was used to calculate LP. Multiple generalized estimating equations (GEE) analysis was used for data analysis. Results: Among the 8089 examined eyes, the mean LP in Phase 1 and 2, and the three-year change were 21.61 ± 1.47D, 21.00 ± 1.42D, and -0.61 ± 0.52D, respectively. The GEE model showed that negative shifts in LP were less pronounced with increasing age (β = 0.176; p < 0.001), and were also less noticeable in hyperopes compared to emmetropes (β = 0.120; p < 0.001). The changes in LP decreased when outdoor activity increased among urban residents (β = 0.013; p = 0.039), while it increased in rural areas (β = -0.020; p = 0.047). The mean three-year change in LT was 0.002 ± 0.13 mm. Female sex and aging by one year increased the LT by 0.022 mm (P < 0.001). However, LT decreased in 6-8-year-olds, while it increased in 10-12-year-old children, both in a linear fashion. The change in LT was less in myopes than in emmetropes (β = -0.018, P-value = 0.010). Conclusion: LP decreases after three years in 6 to 12-year-old children. LT increases slightly after three years in 6 to 12-year-old children. The changes in LP and LT were associated with refractive errors, place of residence, age and gender, and outdoor activity time.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHashemi H, Khabazkhoob M, Azizi E, Iribarren R, Lanca C, Grzybowski A, et al. Longitudinal changes in crystalline lens thickness and power in children aged 6-12 years old. Eye (Lond). 2024;38(7):1283-9.pt_PT
dc.identifier.doi10.1038/s41433-023-02882-5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16728
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNaturept_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41433-023-02882-5pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOrthopticspt_PT
dc.subjectChildrenpt_PT
dc.subjectCrystalline lens powerpt_PT
dc.subjectLens thicknesspt_PT
dc.titleLongitudinal changes in crystalline lens thickness and power in children aged 6-12 years oldpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1289pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1283pt_PT
oaire.citation.titleEyept_PT
oaire.citation.volume38pt_PT
person.familyNameLança
person.givenNameCarla
person.identifier.ciencia-id601A-6412-BF2F
person.identifier.orcid0000-0001-9918-787X
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0320b455-ee19-4670-8bf2-10dce9de1bec
relation.isAuthorOfPublication.latestForDiscovery0320b455-ee19-4670-8bf2-10dce9de1bec

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