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Does the hyperglycemia impact on COVID-19 outcomes depend upon the presence of diabetes? An observational study

2022-11Journal article Open access
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dc.contributor.authorManique, Inês
dc.contributor.authorMatias, Alexandra Abegão
dc.contributor.authorBouça, Bruno
dc.contributor.authorRego, Teresa
dc.contributor.authorCortez, Luísa
dc.contributor.authorSabino, Teresa
dc.contributor.authorPanarra, António
dc.contributor.authorRizzo, Manfredi
dc.contributor.authorSilva-Nunes, José
dc.date.accessioned2022-12-07T15:22:56Z
dc.date.available2022-12-07T15:22:56Z
dc.date.issued2022-11
dc.description.abstractDiabetes mellitus (DM) has emerged as a major risk factor for COVID-19 severity and SARS-CoV-2 infection can worsen glycemic control and may precipitate new-onset diabetes. At-admission hyperglycemia (AH) is a known predictor for worse outcomes in many diseases and seems to have a similar effect in COVID-19 patients. In this study, we aimed to assess the impact of AH regardless of pre-existing diabetes mellitus and new-onset diabetes diagnosis in the clinical severity of COVID-19 inpatients in the first months of the pandemic. A retrospective monocentric study on 374 COVID-19 inpatients (209 males) was developed to assess associations between AH (blood glucose levels in the Emergency Department or the first 24 h of hospitalization greater than 140 mg/dL) and severity outcomes (disease severity, respiratory support, admission to Intensive Care Unit (ICU) and mortality) in patients with and without diabetes. Considering diabetic patients with AH (N = 68;18.1%) there was a correlation with COVID-19 severity (p = 0.03), invasive mechanical ventilation (p = 0.008), and ICU admission (p = 0.026). No correlation was present with any severity outcomes in diabetic patients without AH (N = 33; 8.8%). All of the New-onset Diabetes patients (N = 15; 4%) had AH, and 12 had severe COVID-19; additionally, five patients were admitted to the ICU and three patients died. However, severity outcomes did not reach statistical correlation significance in this group. In nondiabetic patients with AH (N = 51; 13.6%), there was a statistically significant association with the need for oxygen therapy (p = 0.001), invasive mechanical ventilation (p = 0.01), and ICU admission (p = 0.03). Our results support data regarding the impact of AH on severity outcomes. It also suggests an effect of AH on the prognosis of COVID-19 inpatients, regardless of the presence of pre-existing diabetes or new-onset diabetes. We reinforce the importance to assess at admission glycemia in all patients admitted with COVID-19.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationManique I, Matias AA, Bouça B, Rego T, Cortez L, Silva-Nunes J, et al. Does the hyperglycemia impact on COVID-19 outcomes depend upon the presence of diabetes? An observational study. Metabolites. 2022;12(11):1116.pt_PT
dc.identifier.doi10.3390/metabo12111116pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15128
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2218-1989/12/11/1116pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectClinical outcomespt_PT
dc.subjectDiabetespt_PT
dc.subjectDiabetes mellituspt_PT
dc.subjectHyperglycemiapt_PT
dc.titleDoes the hyperglycemia impact on COVID-19 outcomes depend upon the presence of diabetes? An observational studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPage1116pt_PT
oaire.citation.titleMetabolitespt_PT
oaire.citation.volume12pt_PT
person.familyNameSilva-Nunes
person.givenNameJosé António
person.identifier.ciencia-id4B1C-E132-25F0
person.identifier.orcid0000-0002-4728-1220
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9352b380-9661-4316-ab88-6ed9be1020ac
relation.isAuthorOfPublication.latestForDiscovery9352b380-9661-4316-ab88-6ed9be1020ac

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