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Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients

2008-11Journal article Open access
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dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorCarmona, Bruno
dc.contributor.authorGonçalves, Susana
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorFidalgo, Paulo
dc.contributor.authorBrito, Miguel
dc.contributor.authorLeitão, Carlos Nobre
dc.contributor.authorCravo, Marília
dc.date.accessioned2014-01-02T16:29:43Z
dc.date.available2014-01-02T16:29:43Z
dc.date.issued2008-11
dc.description.abstractBackground: Polymorphisms located in genes involved in the metabolism of folate and some methyl-related nutrients are implicated in colorectal cancer (CRC). Objective: We evaluated the association of 3 genetic polymorphisms [C677T MTHFR (methylene tetrahydrofolate reductase), A2756G MTR (methionine synthase), and C1420T SHMT (serine hydroxymethyltransferase)] with the intake of methyl-donor nutrients in CRC risk. Design: Patients withCRC(n 196) and healthy controls (n 200) matched for age and sex were evaluated for intake of methyl-donor nutrients and the 3 polymorphisms. Results: Except for folate intake, which was significantly lower in patients (P 0.02), no differences were observed in the dietary intake of other methyl-donor nutrients between groups. High intake of folate ( 406.7 g/d) was associated with a significantly lower risk of CRC (odds ratio: 0.67; 95% CI: 0.45, 0.99). The A2756G MTR polymorphism was not associated with the risk of developing CRC. In contrast, homozygosity for the C677TMTHFRvariant (TT) presented a 3.0-fold increased risk of CRC (95% CI: 1.3, 6.7). Similarly, homozygosity for the C1420T SHMT polymorphism also had a 2.6-fold increased risk (95% CI: 1.1, 5.9) of developing CRC. When interactions between variables were studied, low intake of all methyl-donor nutrients was associated with an increased risk ofCRC in homozygous participants for the C677T MTHFR polymorphism, but a statistically significant interaction was only observed for folate (odds ratio: 14.0; 95% CI: 1.8, 108.5). No significant associations were seen for MTR or SHMT polymorphisms. Conclusion: These results show an association between the C677T MTHFR variant and different folate intakes on risk of CRC.por
dc.identifier.citationGuerreiro CS, Carmona B, Gonçalves S, Carolino E, Fidalgo P, Brito M, et al. Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients. Am J Clin Nutr. 2008;88(5):1413-8.por
dc.identifier.issn1938-3207
dc.identifier.urihttp://hdl.handle.net/10400.21/3053
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://ajcn.nutrition.org/content/88/5/1413.full.pdf+htmlpor
dc.subject5-Methyltetrahydrofolate-homocysteine S-methyltransferasepor
dc.subjectCase-control studiespor
dc.subjectColorectal neoplasms/por
dc.subjectDose-response relationship, Drugpor
dc.subjectFolic acidpor
dc.subjectGlycine hydroxymethyltransferasepor
dc.subjectMethylenetetrahydrofolate reductasepor
dc.subjectOdds ratiopor
dc.subjectPolymorphismpor
dc.subjectRisk factorpor
dc.titleRisk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrientspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1418por
oaire.citation.startPage1413por
oaire.citation.titleAmerican Journal of Clinical Nutritionpor
oaire.citation.volume88por
person.familyNameCarolino
person.familyNameBrito
person.givenNameElisabete
person.givenNameMiguel
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery77930d39-ed34-44dc-a4a6-9bf833e5e688

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