Repository logo
 
Publication

The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde

2013-04Journal article Restricted access
Simple item page
dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, Manuel C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2013-06-25T14:21:14Z
dc.date.available2013-06-25T14:21:14Z
dc.date.issued2013-04
dc.description.abstractThe International Agency for Research on Cancer classified formaldehyde as carcinogenic to humans because there is “sufficient epidemiological evidence that it causes nasopharyngeal cancer in humans”. Genes involved in DNA repair and maintenance of genome integrity are critically involved in protecting against mutations that lead to cancer and/or inherited genetic disease. Association studies have recently provided evidence for a link between DNA repair polymorphisms and micronucleus (MN) induction. We used the cytokinesis-block micronucleus (CBMN assay) in peripheral lymphocytes and MN test in buccal cells to investigate the effects of XRCC3 Thr241Met, ADH5 Val309Ile, and Asp353Glu polymorphisms on the frequency of genotoxicity biomarkers in individuals occupationally exposed to formaldehyde (n = 54) and unexposed workers (n = 82). XRCC3 participates in DNA double-strand break/recombination repair, while ADH5 is an important component of cellular metabolism for the elimination of formaldehyde. Exposed workers had significantly higher frequencies (P < 0.01) than controls for all genotoxicity biomarkers evaluated in this study. Moreover, there were significant associations between XRCC3 genotypes and nuclear buds, namely XRCC3 Met/Met (OR = 3.975, CI 1.053–14.998, P = 0.042) and XRCC3 Thr/Met (OR = 5.632, CI 1.673–18.961, P = 0.005) in comparison with XRCC3 Thr/Thr. ADH5 polymorphisms did not show significant effects. This study highlights the importance of integrating genotoxicity biomarkers and genetic polymorphisms in human biomonitoring studies.por
dc.identifier.citationLadeira C, Viegas S, Carolino E, Gomes MC, Brito M. The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde. Environ Mol Mutagen. 2013;54(3):213-21.por
dc.identifier.issn0893-6692
dc.identifier.urihttp://hdl.handle.net/10400.21/2581
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley-Blackwellpor
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/em.21755/abstractpor
dc.subjectGenetic susceptibilitypor
dc.subjectGenotoxicity biomarkerspor
dc.subjectOccupational exposurepor
dc.subjectAldehyde oxidoreductases/geneticspor
dc.subjectDNA repair/geneticspor
dc.subjectEnvironmental monitoringpor
dc.subjectFormaldehydepor
dc.subjectToxicitypor
dc.subjectMicronuclei, chromosome-defectivepor
dc.subjectWorkplacepor
dc.titleThe influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehydepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage221por
oaire.citation.startPage213por
oaire.citation.titleEnvironmental and Molecular Mutagenesispor
oaire.citation.volume54por
person.familyNameLadeira
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The influence of genetic polymorphisms in XRCC3 and ADH5 genes on the frequency of genotoxicity biomarkers in workers exposed to formaldehyde.pdf
Size:
110.34 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos