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Risk assessment of exposure to multiple mycotoxins in the Icelandic population

2023-10Conference object Open access
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dc.contributor.authorDurão, J.
dc.contributor.authorEiríksdóttir, A. V.
dc.contributor.authorHalldórsson, ÞI
dc.contributor.authorÓlafsdóttir, K.
dc.contributor.authorTwarużek, M.
dc.contributor.authorKosicki, Robert
dc.contributor.authorViegas, Carla
dc.contributor.authorAssunção, R.
dc.contributor.authorViegas, Susana
dc.contributor.authorMartins, Carla
dc.date.accessioned2024-01-10T10:23:03Z
dc.date.available2024-01-10T10:23:03Z
dc.date.issued2023-10
dc.description.abstractBackground: The proliferation of mycotoxin-producing fungi in agricultural settings poses a challenge to human health and nutrition around the world. Mycotoxins contaminate food sources and their negative health outcomes include carcinogenic, nephrotoxic, and teratogenic effects. Potential risks are still poorly characterized and few studies assess exposure at an individual level. Thus, the goal of this study was to assess and characterize exposure risk to multiple mycotoxins in the Icelandic population. Methods: Urine samples and data on urinary mycotoxin biomarkers (deoxynivalenol, zearalenone, and ochratoxin A) from a pool of 171 individuals living in Iceland between 2020 and 2021 were used to estimate external doses through reverse dosimetry. For risk characterization, Hazard Quotient (HQ) and Margin of Exposure (MoE) approaches were applied for deoxynivalenol zearalenone, and ochratoxin A, respectively. Results: The Icelandic population was revealed to be exposed to multiple mycotoxins. Mean levels of deoxynivalenol and ochratoxin A were comparable to what have been reported in other European studies, while levels of zearalenone were considerably lower. Nevertheless, risk assessment revealed safe levels of exposure to deoxynivalenol and zearalenone (HQ < 1) but MoE based on a neoplastic endpoint to ochratoxin A indicated a possible health concern for all participants (MoE < 10000). Conclusions: Although there are some uncertainties associated with a human biomonitoring approach, the results of this study confirm that mycotoxins are a growing threat to public health in the European continent. Since countries with different latitudes already present comparable levels of exposure, this is especially concerning in a climate change scenario. Further studies both on exposure assessment and specific effects on human health are required to accurately assess risk and introduce preventive measures.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDurão J, Eiríksdóttir AV, Halldórsson ÞI, Ólafsdóttir K, Viegas C, Viegas S, et al. Risk assessment of exposure to multiple mycotoxins in the Icelandic population. In: 16th European Public Health Conference 2023 – Our Food, Our Health, Our Earth: a Sustainable Future for Humanity, Dublin (Ireland), November 8-11, 2023. Eur J Public Health. 2023;33(Suppl 2):ckad160.1076.pt_PT
dc.identifier.doi10.1093/eurpub/ckad160.1076pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16840
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford Academicpt_PT
dc.relation.publisherversionhttps://academic.oup.com/eurpub/article/33/Supplement_2/ckad160.1076/7328084pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHuman exposurept_PT
dc.subjectBiological markerspt_PT
dc.subjectMycotoxinspt_PT
dc.subjectRisk assessmentpt_PT
dc.subjectBiological monitoringpt_PT
dc.subjectIcelandpt_PT
dc.titleRisk assessment of exposure to multiple mycotoxins in the Icelandic populationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.issueSupplement_2pt_PT
oaire.citation.startPageckad160.1076pt_PT
oaire.citation.titleEuropean Journal of Public Healthpt_PT
oaire.citation.volume33pt_PT
person.familyNameViegas
person.familyNameViegas
person.givenNameCarla
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0002-1545-6479
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridB-7217-2013
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id55443609700
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscoveryb5fa5da4-50c3-4b88-ae20-1bc63cb485f7

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