Logo do repositório
 
Publicação

The comet assay as a tool for human biomonitoring of exposure to environmental and occupational agents: a summary of systematic reviews and meta-analyses

2026-07Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorMøller, Peter
dc.contributor.authorGajski, Goran
dc.contributor.authorGerić, Marko
dc.contributor.authorAzqueta, Amaya
dc.contributor.authorGiovannelli, Lisa
dc.contributor.authorHaveric, Anja
dc.contributor.authorStopper, Helga
dc.contributor.authorBankoglu, Ezgi Eyluel
dc.contributor.authorCollins, Andrew
dc.contributor.authorLadeira, Carina
dc.date.accessioned2026-06-25T08:00:09Z
dc.date.available2026-06-25T08:00:09Z
dc.date.issued2026-07
dc.descriptionThis work was supported by the affiliated institutions, European Regional Development Fund project KK.01.1.1.02.0007 (Rec-IMI), the Croatian Science Foundation (HUMNap project #1192), the Horizon Europe (EDIAQI project #101057497), the European Union—Next Generation EU 533–03–23–0006 (BioMolTox), FCT/MCTES UIDP/ 05608/2020, UIDB/05608/2020, and the International Comet Assay Working Group (ICAWG).
dc.description.abstractThis paper compiles results from six systematic reviews and meta-analyses on associations between environmental and occupational exposure to chemicals and levels of DNA strand breaks in human leukocytes, measured by the comet assay. There are no differences in effect sizes when using different comet descriptors. However, lower central tendencies are obtained by using a non-parametric test as compared to the standard parametric analysis, indicating that the standard meta-analyses tend to overestimate the effect size. The compiled results indicate that exposures can be sorted into three groups with decreasing effect size: high (pesticides), moderate (volatile organic compounds, heavy metals, and antineoplastic drugs), and low (anaesthetic gases and air pollution). Interestingly, studies from middle-income countries have higher effect sizes than those seen in studies from high-income countries. This may be related to higher exposures or lower socioeconomic status in middle-income countries. However, there is also some co-variability between studies from middle-income countries and the risk of comet assay measurement bias, assessed as information provided in published papers. Lack of information on assay controls and blinded/coded sample analysis appears to be a general issue in studies on comet assay results. Risk of exposure misclassification is mainly related to the type of exposure; there are good biomarkers for some exposures (e.g., heavy metals), whereas other exposures are more challenging to assess with biomarkers (e.g., pesticides). In conclusion, all examined exposures result in significant increases in DNA strand breaks at the population level, though to varying degrees.eng
dc.description.sponsorshipThis work was supported by the affiliated institutions, European Regional Development Fund project KK.01.1.1.02.0007 (Rec-IMI), the Croatian Science Foundation (HUMNap project #1192), the Horizon Europe (EDIAQI project #101057497), the European Union—Next Generation EU 533–03–23–0006 (BioMolTox), FCT/MCTES UIDP/ 05608/2020, UIDB/05608/2020, and the International Comet Assay Working Group (ICAWG).
dc.identifier.citationMøller P, Gajski G, Gerić M, Azqueta A, Giovannelli L, Ladeira C, et al. The comet assay as a tool for human biomonitoring of exposure to environmental and occupational agents: a summary of systematic reviews and meta-analyses. Mutat Res Rev Mutat Res. 2026;798:108601.
dc.identifier.doi10.1016/j.mrrev.2026.108601
dc.identifier.issn1383-5742
dc.identifier.urihttp://hdl.handle.net/10400.21/22921
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relationEuropean Regional Development Fund project KK.01.1.1.02.0007 (Rec-IMI)
dc.relationHorizon Europe (EDIAQI project #101057497)
dc.relationEuropean Union—Next Generation EU 533–03–23–0006 (BioMolTox)
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S1383574226000177
dc.relation.ispartofMutation Research - Reviews in Mutation Research
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectComet assay
dc.subjectDNA strand breaks
dc.subjectHuman biomonitoring
dc.subjectMeta-analysis
dc.subjectPublic health
dc.subjectSystematic review
dc.subjectEDIAQI project #101057497
dc.subjectFCT_UIDB/05608/2020
dc.subjectFCT_UIDP/05608/2020
dc.titleThe comet assay as a tool for human biomonitoring of exposure to environmental and occupational agents: a summary of systematic reviews and meta-analyseseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage108601
oaire.citation.titleMutation Research - Reviews in Mutation Research
oaire.citation.volume798
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
The comet assay as a tool for human biomonitoring of exposure to environmental and occupational agents_a summary of systematic reviews and meta-analyses.pdf
Tamanho:
3.93 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
4.03 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

ESSL - Artigos