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Pregnancy surveillance in sickle cell disease patients: a cohort study in an African country – Angola

2022-12Conference object Open access
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dc.contributor.authorBrito, Miguel
dc.contributor.authorGinete, Catarina
dc.contributor.authorFerreira, Joana
dc.contributor.authorMendes, Manuela
dc.contributor.authorVasconcelos, Jocelyne
dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorSebastião, Cruz
dc.contributor.authorQuinto, Francisco
dc.contributor.authorSimão, Fernanda
dc.contributor.authorMateus, Anabela
dc.contributor.authorFernandes, Filipe
dc.date.accessioned2023-08-30T13:27:59Z
dc.date.available2023-08-30T13:27:59Z
dc.date.issued2022-12
dc.descriptionThis project is funded by Fundação Calouste Gulbenkian, Portugal, and by Instituto Camões - Instituto da Cooperação e da Língua, I.P.pt_PT
dc.description.abstractSickle Cell Disease (SCD) is a severe monogenic disease caused by the inherence of a recessive mutation in the β-globin gene, with an especially high prevalence in sub-Saharan Africa. In Angola, the prevalence of the disease is almost 2%, and the carriers reach 21% of the population. Although its presentation tends to be very heterogeneous, chronic hemolytic anemia, frequent painful crises, and extensive organ damage are common features of these patients. Pregnancy in SCD patients is associated with an increase in severe outcomes, namely, a high risk of eclampsia and pre-eclampsia, stroke, and even death. Therefore, it is crucial to maintain continuous medical surveillance during pregnancy, especially in women with previous strokes. Moreover, health services in low- and middle-income countries are generally not prepared to follow these patients. The present cohort study, conducted at the Lucrecia Paim Maternity Hospital (Luanda, Angola), aims to determine pregnancy complications in SCD women, especially those responsible for maternal death, and, by supporting the obstetric consultations in this hospital, contribute to the reduction of mortality and morbidity rates. Pregnancy monitoring includes analysis of clinical history and incidents (number of hospitalizations, blood transfusions, strokes, and other clinical complications), hematological and biochemical analysis, transcranial Doppler to assess cerebral hemodynamics, and genetic analysis (confirmation of the diagnosis, genotyping of four SNPs in the β-cluster to assess the haplotype, and evaluation of the presence of the 3.7kb deletion of the α-globin gene).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBrito M, Ginete C, Ferreira J, Mendes M, Vasconcelos J, Fernandes F, et al. Pregnancy surveillance in sickle cell disease patients: a cohort study in an African country – Angola. In: 64th ASH Annual Meeting & Exposition, New Orleans (Louisiana, USA), December 10-13, 2022. Blood. 2022;140 (Suppl 1):5397-8.pt_PT
dc.identifier.doi10.1182/blood-2022-159681pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16432
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://ashpublications.org/blood/article/140/Supplement%201/5397/491823/Pregnancy-Surveillance-in-Sickle-Cell-Diseasept_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectPregnancypt_PT
dc.subjectAngolapt_PT
dc.titlePregnancy surveillance in sickle cell disease patients: a cohort study in an African country – Angolapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleBloodpt_PT
person.familyNameBrito
person.familyNameHonrado Ginete
person.familyNameCardoso Ferreira
person.familyNameNeves Delgadinho
person.givenNameMiguel
person.givenNameAna Catarina
person.givenNameJoana
person.givenNameMariana Isabel
person.identifierA-8277-2012
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-idA910-13EB-21D1
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0002-9438-4185
person.identifier.orcid0000-0003-0586-9154
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id7403252327
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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