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Methodological quality and clinical recommendations of guidelines on the management of dyslipidaemias for cardiovascular disease risk reduction: a systematic review and an appraisal through AGREE II and AGREE REX tools

2024-10Journal article Restricted access
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dc.contributor.authorDeffert, Flávia
dc.contributor.authorVilela, Ana Paula
dc.contributor.authorCobre, Alexandre de Fátima
dc.contributor.authorFurlan, Luiz Henrique
dc.contributor.authorTonin, Fernanda
dc.contributor.authorFernandez-Lllimos, Fernando
dc.contributor.authorPontarolo, Roberto
dc.date.accessioned2024-06-17T10:27:49Z
dc.date.embargo2026-06-17
dc.date.issued2024-10
dc.descriptionThis research was funded by Coordination for the Improvement of Higher Education Personnel—Brazil (CAPES), grant number 001.pt_PT
dc.description.abstractBackground: Clinical practice guidelines (CPGs) are statements to assist practitioners and stakeholders in decisions about healthcare. Low methodological quality guidelines may prejudice decision-making and negatively affect clinical outcomes in non-communicable diseases, such as cardiovascular diseases worsted by poor lipid management. We appraised the quality of CPGs on dyslipidemia management and synthesized the most updated pharmacological recommendations. Methods: A systematic review following international recommendations was performed. Searches to retrieve CPG on pharmacological treatments in adults with dyslipidaemia were conducted in PubMed, Scopus, and Trip databases. Eligible articles were assessed using AGREE II (methodological quality) and AGREE-REX (recommendation excellence) tools. Descriptive statistics were used to summarize data. The most updated guidelines (published after 2019) had their recommendations qualitatively synthesized in an exploratory analysis. Results: Overall, 66 guidelines authored by professional societies (75%) and targeting clinicians as primary users were selected. The AGREE II domains Scope and Purpose (89%) and Clarity of Presentation (97%), and the AGREE-REX item Clinical Applicability (77.0%) obtained the highest values. Conversely, guidelines were methodologically poorly performed/documented (46%) and scarcely provided data on the implementability of practical recommendations (38%). Recommendations on pharmacological treatments are overall similar, with slight differences concerning the use of supplements and the availability of drugs. Conclusion: High-quality dyslipidaemia CPG, especially outside North America and Europe, and strictly addressing evidence synthesis, appraisal, and recommendations are needed, especially to guide primary care decisions. CPG developers should consider stakeholders' values and preferences and adapt existing statements to individual populations and healthcare systems to ensure successful implementation interventions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDeffert F, Vilela AP, Cobre AF, Furlan LH, Tonin FS, Fernandez-Lllimos F, et al. Methodological quality and clinical recommendations of guidelines on the management of dyslipidaemias for cardiovascular disease risk reduction: a systematic review and an appraisal through AGREE II and AGREE REX tools. Fam Pract. 2024;41(5):649-61.pt_PT
dc.identifier.doi10.1093/fampra/cmae029pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17500
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford Academicpt_PT
dc.relation.publisherversionhttps://academic.oup.com/fampra/advance-article-abstract/doi/10.1093/fampra/cmae029/7687221?redirectedFrom=fulltext&login=truept_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDyslipidemiapt_PT
dc.subjectPractice guidelinespt_PT
dc.subjectQuality assurancept_PT
dc.subjectHealth carept_PT
dc.subjectQuality of healthcarept_PT
dc.subjectCardiovascular diseasept_PT
dc.titleMethodological quality and clinical recommendations of guidelines on the management of dyslipidaemias for cardiovascular disease risk reduction: a systematic review and an appraisal through AGREE II and AGREE REX toolspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage661pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage649pt_PT
oaire.citation.titleFamily Practicept_PT
oaire.citation.volume41pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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