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Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: a cross-sectional analysis

2025-04Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMüller, Alexander
dc.contributor.authorWouters, Emiel F.
dc.contributor.authorBurney, Peter
dc.contributor.authorPotts, James
dc.contributor.authorCardoso, Joao
dc.contributor.authorAl Ghobain, Mohammed
dc.contributor.authorStudnicka, Michael
dc.contributor.authorObaseki, Daniel
dc.contributor.authorElsony, Asma
dc.contributor.authorMortimer, Kevin
dc.contributor.authorMannino, David
dc.contributor.authorJögi, Rain
dc.contributor.authorAhmed, Rana
dc.contributor.authorNafees, Asaad
dc.contributor.authorHermínia Brites Dias
dc.date.accessioned2025-04-03T16:04:36Z
dc.date.available2025-04-03T16:04:36Z
dc.date.issued2025-04
dc.description.abstractIntroduction: Evidence of an association between breathlessness and quality of life from population-based studies is limited. We aimed to investigate the association of physical and mental quality of life with breathlessness across several low-, middle- and high-income countries. Methods: We analyzed data from 19,714 adults (31 sites, 25 countries) from the Burden of Obstructive Lung Disease (BOLD) study. We measured both mental and physical quality of life components using the SF-12 questionnaire and defined breathlessness as grade ≥2 on the modified Medical Research Council scale. We used multivariable linear regression to assess the association of each quality-of-life component with breathlessness. We pooled site-specific estimates using random-effects meta-analysis. Results: Both physical and mental component scores were lower in participants with breathlessness compared to those without. This association was stronger for the physical component (coefficient = -7.59; 95%CI -8.60, -6.58; I2 = 78.5%) than for the mental component (coefficient = -3.50; 95%CI -4.36, -2.63; I2 = 71.4%). The association between physical components and breathlessness was stronger in high-income countries (coefficient = -8.82; 95%CI -10.15, -7.50). Heterogeneity across sites was partly explained by sex and tobacco smoking. Conclusion: Quality of life is worse in people with breathlessness, but this association varies widely across the world.eng
dc.identifier.citationMüller A, Wouters EF, Burney P, Potts J, Cardoso J, Dias HB, et al. Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: a cross-sectional analysis. Pulmonology. 2025;31(1):2470566.
dc.identifier.doi10.1080/25310429.2025.2470566
dc.identifier.urihttp://hdl.handle.net/10400.21/21745
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/25310429.2025.2470566
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDyspnoea
dc.subjectBreathlessness
dc.subjectQuality of life
dc.subjectBOLD study
dc.titleQuality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: a cross-sectional analysiseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPage2470566
oaire.citation.titlePulmonology
oaire.citation.volume31
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDias
person.givenNameMaria Hermínia Monteiro Brites
person.identifier.ciencia-idE211-FB1B-04E3
person.identifier.orcid0000-0003-1257-8734
person.identifier.ridAFL-8310-2022
person.identifier.scopus-author-id55671930200
relation.isAuthorOfPublicationb7b7e7d9-83b2-4d63-9176-4ed73cf6b939
relation.isAuthorOfPublication.latestForDiscoveryb7b7e7d9-83b2-4d63-9176-4ed73cf6b939

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