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Evaluation of the attenuation correction on myocardial perfusion imaging: a phantom study

2019-02Journal article Open access
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dc.contributor.authorMachado, Marisa
dc.contributor.authorOliveira, Francisco P. M.
dc.contributor.authorVieira, Lina Oliveira
dc.contributor.authorCosta, Durval C.
dc.date.accessioned2019-07-31T16:09:38Z
dc.date.available2019-07-31T16:09:38Z
dc.date.issued2019-02
dc.description.abstractMyocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is important for risk stratification of coronary artery disease. MPI quantification obtained from available images may not be accurate due to several potential sources of error, being photon attenuation, especially in overweight patients, a significant problem. Attenuation maps derived from X-ray computed tomography (CT) may be used to correct for photon attenuation. The aim of this study was to evaluate the effects of non-attenuation correction (NAC) and attenuation correction (AC) in MPI SPECT imaging using anthropomorphic phantoms simulating patients with different attenuation profiles. Forty-nine SPECT and CT studies of Heart/Thorax phantoms with different attenuation layers were acquired. All SPECT imaging data were reconstructed with and without AC. Quantification of the myocardial signal (uptake) was performed in four regions of interest: septum, anterior wall, inferior wall, and apex. This was done both in NAC and AC SPECT images. A qualitative evaluation was performed by a nuclear medicine physician also in NAC and AC SPECT images. The results demonstrated, as expected, statistically lower counts when the thickness of the phantom attenuating material increased and attenuation correction was lacking. On the other hand, when attenuation correction was applied, there were no statistically significant count differences whatever the thickness of the phantom attenuating material. In the qualitative evaluation, the nuclear medicine physician observed small variations in the anterior wall uptake according to the various conditions under test. However, the changes were not statistically significant. In conclusion, there is no evidence that the effects of attenuation in overweight patients are not properly corrected when the MPI SPECT images are reconstructed with CT-based AC. In terms of qualitative visual assessment, there is no significant variation in the classification of myocardial walls uptake with and without AC when the evaluation is done by an experienced physician.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado M, Oliveira FP, Vieira L, Costa DC. Evaluation of the attenuation correction on myocardial perfusion imaging: a phantom study. In: 2019 IEEE 6th Portuguese Meeting on Bioengineering (ENBENG).pt_PT
dc.identifier.doi10.1109/ENBENG.2019.8692480pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/10393
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInstitute of Electrical and Electronics Engineerspt_PT
dc.relation.publisherversionhttps://ieeexplore.ieee.org/document/8692480pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNuclear medicinept_PT
dc.subjectSPECTpt_PT
dc.subjectAttenuation correctionpt_PT
dc.subjectComputed tomographypt_PT
dc.subjectMyocardial perfusion imagingpt_PT
dc.subjectPhantom studypt_PT
dc.subjectPneumodynamicspt_PT
dc.subjectMedical image processingpt_PT
dc.subjectImage reconstructionpt_PT
dc.subjectImage motion analysispt_PT
dc.titleEvaluation of the attenuation correction on myocardial perfusion imaging: a phantom studypt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameVieira
person.givenNameLina Oliveira
person.identifier.ciencia-idD316-5085-2DE0
person.identifier.orcid0000-0002-7109-6535
person.identifier.ridP-7426-2015
person.identifier.scopus-author-id55258594400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0b528961-126c-42d6-a4e7-2a10423c94b8
relation.isAuthorOfPublication.latestForDiscovery0b528961-126c-42d6-a4e7-2a10423c94b8

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