Repository logo
 
Publication

Unacylated ghrelin does not seem to influence glucose homeostasis in obese women

2017-05Conference object Open access
Simple item page
dc.contributor.authorSilva-Nunes, José
dc.contributor.authorBrito, Miguel
dc.contributor.authorSilva, Carina
dc.contributor.authorOliveira, Ana Cebola
dc.contributor.authorVeiga, Luísa
dc.date.accessioned2017-12-11T16:56:10Z
dc.date.available2017-12-11T16:56:10Z
dc.date.issued2017-05
dc.description.abstractBackground and Aim: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a non-functional peptide, soon after UAG has been associated with a negative action on energy balance, suppression of hepatic glucose production and a decrease in circulating levels of insulin. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from the eventual interference of adiposity. Material and Methods: One hundred lean and 254 obese Caucasian women were studied. Each woman was characterized for total body weight, body mass index (BMI), waist and hip circumferences, glucose at fasting and 2 hours after an oral glucose tolerance test (OGTT), fasting insulin, glycated hemoglobin (HbA1c), and UAG. Insulin resistance was assessed by the homeostasis model assessment (HOMA-IR). Obese women were classified into three glycemic status subgroups (normoglycemia, prediabetes, and diabetes) according to HbA1c and glucose values. Results: When compared with the lean group, significantly lower UAG levels were observed in obese women when compared with the lean group (350.2±251.9 vs 219.2±149.7 pg/ml; P<0.001). However, no significant difference was observed through obesity classes I to III. UAG levels were not significantly different among glycemic status subgroups and did not show any direct association with glucose, insulin, HOMA-IR, or HbA1c values. Conclusions: Although the level of the unacylated form of ghrelin shows an association with anthropometrics it seems not to be involved in glucose homeostasis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva-Nunes J, Brito M, Silva C, Oliveira A, Veiga L. Unacylated ghrelin does not seem to influence glucose homeostasis in obese women. In: 19th European Congress of Endocrinology 2017, 20-23 May 2017, Lisbon (Portugal). Endocr Abs. 2017;49:EP451.pt_PT
dc.identifier.doi10.1530/endoabs.49.EP451pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7680
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioScientificapt_PT
dc.relation.publisherversionhttp://www.endocrine-abstracts.org/ea/0049/ea0049ep451.htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEndocrinologypt_PT
dc.subjectObesitypt_PT
dc.subjectWomanpt_PT
dc.subjectGlucose homeostasispt_PT
dc.subjectUnacylated ghrelinpt_PT
dc.subjectAnthropometricspt_PT
dc.titleUnacylated ghrelin does not seem to influence glucose homeostasis in obese womenpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPageEP451pt_PT
oaire.citation.startPageEP451pt_PT
oaire.citation.titleEndocrine Abstractspt_PT
oaire.citation.volume49pt_PT
person.familyNameBrito
person.familyNameVeiga
person.givenNameMiguel
person.givenNameLuisa
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0003-1153-8343
person.identifier.ridA-7970-2016
person.identifier.ridL-2730-2013
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id8318978600
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication.latestForDiscoveryaac1914a-275f-4be2-819d-ab41d356b45a

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Unacylated ghrelin does not seem to influence glucose homeostasis in obese women.pdf
Size:
7.63 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Posters