Repository logo
 
Publication

Addressing challenges to enhance clinical research in Portugal: insights from the OncoT3 Expert Group Delphi Study

2024-11Journal article Open access
Simple item page
dc.contributor.authorResende, Catarina
dc.contributor.authorAbreu, Marta
dc.contributor.authorPresa Ramos, José
dc.contributor.authorCarda, José
dc.contributor.authorCosta, Luís
dc.contributor.authorCardoso, Fátima
dc.contributor.authorPereira, Deolinda
dc.contributor.authorTeixeira, Encarnação
dc.contributor.authorTonin, Fernanda
dc.contributor.authorDuarte-Ramos, Filipa
dc.date.accessioned2024-12-27T13:40:30Z
dc.date.available2024-12-27T13:40:30Z
dc.date.issued2024-11
dc.description.abstractIntroduction Over the past decades, clinical research has evolved significantly, driven by advances in regulatory frameworks, technological innovations, and methodological approaches. In Portugal, while there has been progress - such as increased regulatory alignment with European standards and the adoption of digital trial management tools - various challenges remain. These may include, among others, limited access to funding, slower patient recruitment rates, and regulatory hurdles that can delay trial approvals. Our goal was to identify key areas for improvement toward the optimization of clinical research practices in the country. Methods A modified three-round Delphi study was conducted online (2023-2024) to achieve a nationwide expert consensus. The scientific committee, composed of seven experts, developed 45 initial statements across five topics: dedication time to clinical research, organization of integrated research centers, conditions for implementing clinical trials, the role of institutional authorities, and patient recruitment and referral. A five-point Likert-type scale was used (1 - 'strongly disagree', 2 - 'disagree', 3 - 'neither agree nor disagree', 4 - 'agree', and 5 - 'strongly agree') to rate each statement. The consensus threshold was established as a percentage of agreement among participants (≥90% in the first round and ≥85% in the second round). The level of consensus achieved by the panel was discussed by the scientific committee during virtual meetings. Results Fifty-one experts completed the exercise (86.4% response rate). Consensus was reached on 32 of the 45 initial statements (71.1%) in the first round, with most of them (n = 20, or 62.5%) presenting high concordance rates (>95%). Four new statements were added for the second round, grounded on the feedback from the experts. By the end of the study, consensus was achieved on 45 out of the 49 final statements (91.8%), with the greatest agreement on the organization of integrated research centers and conditions for implementing clinical trials. Three statements regarding patient recruitment and referral, and one statement on the role of institutional authorities to promote clinical research, did not reach consensus, highlighting the need for further dialogue and innovative solutions in these fields. Conclusion The insights of this study can inform health organizations, regulatory agencies, and other stakeholders about the barriers and opportunities to improve clinical research in Portugal. By learning from global best practices and tailoring strategies to local contexts, the country can become a more prominent player in the international community.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationResende C, Abreu M, Presa Ramos J, Carda J, Costa L, Tonin FS, et al. Addressing challenges to enhance clinical research in Portugal: insights from the OncoT3 Expert Group Delphi Study. Cureus. 2024;16(11):e73720.pt_PT
dc.identifier.doi10.7759/cureus.73720pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/18083
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.cureus.com/articles/314015-addressing-challenges-to-enhance-clinical-research-in-portugal-insights-from-the-oncot3-expert-group-delphi-study#!/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectClinical researchpt_PT
dc.subjectClinical trialpt_PT
dc.subjectDelphi methodpt_PT
dc.subjectResearch frameworkpt_PT
dc.subjectPortugalpt_PT
dc.titleAddressing challenges to enhance clinical research in Portugal: insights from the OncoT3 Expert Group Delphi Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.startPagee73720pt_PT
oaire.citation.titleCureuspt_PT
oaire.citation.volume16pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Addressing challenges to enhance clinical research in Portugal_insights from the OncoT3 Expert Group Delphi Study.pdf
Size:
813.41 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos