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Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics

2016-07Journal article Restricted access
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dc.contributor.authorCardoso, Rita
dc.contributor.authorSoares, Helena
dc.contributor.authorHemphill, Andrew
dc.contributor.authorLeitão, Alexandre
dc.date.accessioned2016-08-10T16:06:24Z
dc.date.available2016-08-10T16:06:24Z
dc.date.issued2016-07
dc.description.abstractInvasive stages of apicomplexan parasites require a host cell to survive, proliferate and advance to the next life cycle stage. Once invasion is achieved, apicomplexans interact closely with the host cell cytoskeleton, but in many cases the different species have evolved distinct mechanisms and pathways to modulate the structural organization of cytoskeletal filaments. The host cell cytoskeleton is a complex network, largely, but not exclusively, composed of microtubules, actin microfilaments and intermediate filaments, all of which are modulated by associated proteins, and it is involved in diverse functions including maintenance of cell morphology and mechanical support, migration, signal transduction, nutrient uptake, membrane and organelle trafficking and cell division. The ability of apicomplexans to modulate the cytoskeleton to their own advantage is clearly beneficial. We here review different aspects of the interactions of apicomplexans with the three main cytoskeletal filament types, provide information on the currently known parasite effector proteins and respective host cell targets involved, and how these interactions modulate the host cell physiology. Some of these findings could provide novel targets that could be exploited for the development of preventive and/or therapeutic strategies.pt_PT
dc.identifier.citationCardoso R, Soares H, Hemphill A, Leitão A. Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics. Parasitology. 2016;143(8):957-70.pt_PT
dc.identifier.doi10.1017/S0031182016000524pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6351
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCambridge University Presspt_PT
dc.relation.publisherversionhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=10345907&fileId=S0031182016000524pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectApicomplexapt_PT
dc.subjectHost-parasite interactionpt_PT
dc.subjectActinpt_PT
dc.subjectMicrotubulespt_PT
dc.subjectIntermediate filamentspt_PT
dc.titleApicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamicspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage970pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage957pt_PT
oaire.citation.titleParasitology -Cambridge-pt_PT
oaire.citation.volume143pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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