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Internal dose of particles in the elderly: modeling based on aerosol measurements

2018-08Journal article Open access
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dc.contributor.authorAlmeida-Silva, Marina
dc.contributor.authorPilou, Marika
dc.contributor.authorHousiadas, Christos
dc.contributor.authorAlmeida, Susana M.
dc.date.accessioned2018-09-21T09:25:39Z
dc.date.available2018-09-21T09:25:39Z
dc.date.issued2018-08
dc.description.abstractThe paper presents an integrated methodology that combines experimental and modeling techniques and links exposure to airborne particulate matter (PM) with internal dose in the respiratory system and burden in adjacent tissues over a period of time. The methodology is used to estimate doses in the respiratory systems of elders that reside in 10 elderly care centers (ECCs) in the metropolitan area of Lisbon. Measurements of PM were performed in the ECCs and combined with a time-budget survey for the occupants. This information served as input to the first model that estimated particle doses in the different regions of the respiratory tract of the elderly, and then a second model was used to calculate particle build-up in the alveolar region, the interstitium and the hilar lymph nodes of the elders over a 5-year exposure period. It was found that in 5 years of continuous exposure to the average particle concentration measured over all ECCs, 258 mg of all particles are deposited on the surface of the alveoli of which 79.6% are cleared, 18.8% are retained in the alveolar region, 1.5% translocate to the hilar lymph nodes, and 0.1% are transferred to the interstitium.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlmeida-Silva M, Pilou M, Housiadas C, Almeida SM. Internal dose of particles in the elderly: modeling based on aerosol measurements. Environ Sci Pollut Res. 2018;25(24):23645-56.pt_PT
dc.identifier.doi10.1007/s11356-018-2661-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/8871
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs11356-018-2661-3pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEnvironmental healthpt_PT
dc.subjectParticulate matterpt_PT
dc.subjectElderlypt_PT
dc.subjectDepositionpt_PT
dc.subjectHuman respiratory tractpt_PT
dc.subjectClearancept_PT
dc.titleInternal dose of particles in the elderly: modeling based on aerosol measurementspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage23656pt_PT
oaire.citation.issue24pt_PT
oaire.citation.startPage23645pt_PT
oaire.citation.titleEnvironmental Science and Pollution Researchpt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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