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How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia

2022-08Journal article Open access
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dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorGinete, Catarina
dc.contributor.authorSantos, Brígida
dc.contributor.authorFernandes, Carolina
dc.contributor.authorSilva, Carina
dc.contributor.authorMiranda, Armandina
dc.contributor.authorVasconcelos, Jocelyne Neto de
dc.contributor.authorBrito, Miguel
dc.date.accessioned2022-08-22T14:54:09Z
dc.date.available2022-08-22T14:54:09Z
dc.date.issued2022-08
dc.descriptionFCT/Aga Khan (project no. 330842553).pt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractSickle cell anemia (SCA) is an inherited hematological disorder and a serious global health problem, especially in Sub-Saharan Africa. Although hydroxyurea (HU) is the leading treatment for patients with SCA, its effects on the gut microbiome have not yet been explored. In this context, the aim of this study was to investigate this association by characterizing the gut microbiome of an Angolan SCA pediatric population before and after 6 months of HU treatment. A total of 66 stool samples were obtained and sequenced for the 16S rRNA gene (V3-V4 regions). Significant associations were observed in alpha and beta-diversity, with higher values of species richness for the children naïve for HU. We also noticed that children after HU had higher proportions of several beneficial bacteria, mostly short-chain fatty acids (SCFAs) producing species, such as Blautia luti, Roseburia inulinivorans, Eubacterium halli, Faecalibacterium, Ruminococcus, Lactobacillus rogosae, among others. In addition, before HU there was a higher abundance of Clostridium_g24, which includes C. bolteae and C. clostridioforme, both considered pathogenic. This study provides the first evidence of the HU effect on the gut microbiome and unravels several microorganisms that could be considered candidate biomarkers for disease severity and HU efficacy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDelgadinho M, Ginete C, Santos B, Fernandes C, Silva C, Brito M, et al. How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia. Int J Mol Sci. 2022;23(16):9061.pt_PT
dc.identifier.doi10.3390/ijms23169061pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14922
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFCT/Aga Khan (project no. 330842553)pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/16/9061pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHydroxyureapt_PT
dc.subjectGut microbiomept_PT
dc.subjectSickle cell anemiapt_PT
dc.subject16S rRNApt_PT
dc.subjectChildrenpt_PT
dc.subjectAngolapt_PT
dc.subjectFCT_Aga Khan (project no. 330842553)pt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020.pt_PT
dc.titleHow hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue16pt_PT
oaire.citation.startPage9061pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume23pt_PT
person.familyNameNeves Delgadinho
person.familyNameHonrado Ginete
person.familyNameSilva
person.familyNameBrito
person.givenNameMariana Isabel
person.givenNameAna Catarina
person.givenNameCarina
person.givenNameMiguel
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-id2411-5936-0820
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0003-1021-7935
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id55258764900
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationca55aab6-9a58-4f79-ab79-20513414099f
relation.isAuthorOfPublicationdfb2fbba-17ff-42fb-905a-fcfc8f326e1c
relation.isAuthorOfPublication81a5cd80-1982-43ba-bde5-4c43ae0e5234
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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