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Noncoding RNAs as critical players in regulatory accuracy, redox signaling, and immune cell functions

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dc.contributor.authorGomes, Anita Quintal
dc.contributor.authorReal, C.
dc.contributor.authorAntunes, F.
dc.contributor.authorMarinho, H. Susana
dc.contributor.authorNolasco, Sofia
dc.contributor.authorSoares, Helena
dc.date.accessioned2017-08-21T10:21:58Z
dc.date.available2017-08-21T10:21:58Z
dc.date.issued2017
dc.description.abstractThe transcriptome of multicellular organisms is much more complex than initially thought because it includes a large number of noncoding RNAs (ncRNAs). Data regarding ncRNAs suggest that organism complexity better correlates with the percentage of each genome that is transcribed into these molecules. The most studied classes of ncRNAs are short interfering RNAs, microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), and long noncoding RNAs (lncRNAs). In this chapter, we review the biogenesis pathways and general functions of miRNAs, piRNAs, and lncRNAs. We focus on the roles of miRNAs and lncRNAs in gene expression regulation, centering on redox signaling and immune cell development, and highlight some implications for human pathologies. Finally, we analyze current knowledge concerning the use of ncRNAs in diagnosis, prognosis, and therapeutics, and discuss their role in the development of the immune system and the regulatory functions of H2O2 during the course of metazoan evolution.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes AQ, Real C, Antunes F, Marinho HS, Nolasco S, Soares H. Noncoding RNAs as critical players in regulatory accuracy, redox signaling, and immune cell functions. In: Soccol, Pandey, Resende, editors. Current developments in biotechnology and bioengineering: human and animal health applications. Amsterdam: Elsevier Science & Technology; 2017. p. 215-84.pt_PT
dc.identifier.doi10.1016/B978-0-444-63660-7.00010-3pt_PT
dc.identifier.isbn9780444636607
dc.identifier.urihttp://hdl.handle.net/10400.21/7330
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/B9780444636607000103pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBiologypt_PT
dc.subjectImmune cell developmentpt_PT
dc.subjectlncRNAspt_PT
dc.subjectmiRNAspt_PT
dc.subjectncRNAs in diagnosispt_PT
dc.subjectncRNAs in prognosispt_PT
dc.subjectNoncoding RNAspt_PT
dc.subjectpiRNAspt_PT
dc.subjectRedox signalingpt_PT
dc.subjectTherapeutic value of ncRNAspt_PT
dc.titleNoncoding RNAs as critical players in regulatory accuracy, redox signaling, and immune cell functionspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage284pt_PT
oaire.citation.startPage215pt_PT
oaire.citation.titleCurrent developments in biotechnology and bioengineeringpt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typebookPartpt_PT

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