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18F-FDG measurement in primary lung cancer: SUV normalization to different distribution volumes

2014-05Conference object Open access
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dc.contributor.authorBadgi, Estevão
dc.contributor.authorSantos, Beatriz
dc.contributor.authorLucena, Filipa
dc.contributor.authorConde, Isabel
dc.date.accessioned2016-01-14T15:54:05Z
dc.date.available2016-01-14T15:54:05Z
dc.date.issued2014-05
dc.description.abstractIntroduction: Standard Uptake Value (SUV) is a measurement of the uptake in a tumour normalized on the basis of a distribution volume and is used to quantify 18F-Fluorodeoxiglucose (FDG) uptake in tumors, such as primary lung tumor. Several sources of error can affect its accuracy. Normalization can be based on body weight, body surface area (BSA) and lean body mass (LBM). The aim of this study is to compare the influence of 3 normalization volumes in the calculation of SUV: body weight (SUVW), BSA (SUVBSA) and LBM (SUVLBM), with and without glucose correction, in patients with known primary lung tumor. The correlation between SUV and weight, height, blood glucose level, injected activity and time between injection and image acquisition is evaluated. Methods: Sample included 30 subjects (8 female and 22 male) with primary lung tumor, with clinical indication for 18F-FDG Positron Emission Tomography (PET). Images were acquired on a Siemens Biography according to the department’s protocol. Maximum pixel SUVW was obtained for abnormal uptake focus through semiautomatic VOI with Quantification 3D isocontour (threshold 2.5). The concentration of radioactivity (kBq/ml) was obtained from SUVW, SUVBSA, SUVLBM and the glucose corrected SUV were mathematically obtained. Results: Statistically significant differences between SUVW, SUVBSA and SUVLBM and between SUVWgluc, SUVBSAgluc and SUVLBMgluc were observed (p=0.000<0.05). The blood glucose level showed significant positive correlations with SUVW (r=0.371; p=0.043) and SUVLBM (r=0.389; p=0.034). SUVBSA showed independence of variations with the blood glucose level. Conclusion: The measurement of a radiopharmaceutical tumor uptake normalized on the basis of different distribution volumes is still variable. Further investigation on this subject is recommended.pt_PT
dc.identifier.citationBadgi E, Santos B, Lucena F, Conde I. 18F-FDG measurement in primary lung cancer: SUV normalization to different distribution volumes. In International Conference of Nuclear Medicine Technologies & X Seminar of Nuclear Medicine from Lisbon School of Health Technology, Lisbon, 30-31 May 2014.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/5549
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://sites.estesl.ipl.pt/icnmt/wp-content/uploads/2014/05/AbstractBook_IICNMT_final_julho.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectNuclear medicinept_PT
dc.subjectPrimary lung cancerpt_PT
dc.subjectStandard Uptake Valuept_PT
dc.subjectSUVpt_PT
dc.subject18F-Fluorodeoxiglucosept_PT
dc.subjectFDGpt_PT
dc.title18F-FDG measurement in primary lung cancer: SUV normalization to different distribution volumespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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