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Comet assay as a human biomonitoring tool: application in occupational exposure to antineoplastic drugs

2015-09Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorPádua, Mário
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, Manuel
dc.contributor.authorBrito, Miguel
dc.date.accessioned2016-08-29T09:28:02Z
dc.date.available2016-08-29T09:28:02Z
dc.date.issued2015-09
dc.description.abstractAntineoplastic drugs are a heterogeneous group of chemicals used in the treatment of cancer, and have been proved by IARC to be mutagens, carcinogens and teratogens agents. In general, chemicals that interact directly with DNA by biding covalently or by intercalating, or indirectly by interfering with DNA synthesis, were among the first chemotherapeutics developed. Also, these drugs can induce reactive oxygen species that can lead to DNA damage and, consequently, mutations. These drugs are often used in combination to achieve synergistic effects on tumour cells resulting from their differing modes of action. However, most if not all of these chemical agents are generally nonselective and, along with tumour cells, normal cells may undergo cytotoxic/genotoxic damage. The in vivo exposure to antineoplastic drugs has been shown to induce different types of lesions in DNA, depending on the particular stage of cell cycle at the time of treatment. Besides the patients that use these drugs as a treatment, workers that handle and/or administer these drugs can be exposed to these substances; namely pharmacy, and nursing personnel in hospital context.pt_PT
dc.identifier.citationLadeira C, Viegas S, Pádua M, Carolino E, Gomes MC, Brito M. Comet assay as a human biomonitoring tool: application in occupational exposure to antineoplastic drugs. In: Front Genet. Conference Abstract: ICAW 2015 – 11th International Comet Assay Workshop, Antwerpen, Belgium, 1st to 4th September 2015.pt_PT
dc.identifier.doi10.3389/conf.fgene.2015.01.00019pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6414
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://www.frontiersin.org/10.3389/conf.fgene.2015.01.00019/event_abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectDNA damagept_PT
dc.subjectComet assaypt_PT
dc.subject8-OHdGpt_PT
dc.subjectOGG1 polymorphismspt_PT
dc.subjectAntineoplastic drugspt_PT
dc.titleComet assay as a human biomonitoring tool: application in occupational exposure to antineoplastic drugspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleFrontiers in Geneticspt_PT
oaire.citation.volume6pt_PT
person.familyNameLadeira
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id1216-EFA3-1E0F
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person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
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relation.isAuthorOfPublication.latestForDiscovery77930d39-ed34-44dc-a4a6-9bf833e5e688

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