Repository logo
 
Publication

Immunoglobulin serum concentrations do not correlate with acute appendicitis

2022-12Journal article Open access
Simple item page
dc.contributor.authorCarvalho, Nuno
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorCarvalho, Isabel
dc.contributor.authorLisboa, Vanessa
dc.contributor.authorCoelho, Hélder
dc.contributor.authorTrindade, Madalena
dc.contributor.authorVaz, João
dc.contributor.authorMoita, Luís
dc.contributor.authorCosta, Paulo
dc.date.accessioned2023-01-30T12:25:16Z
dc.date.available2023-01-30T12:25:16Z
dc.date.issued2022-12
dc.description.abstractAs imunoglobulinas são um componente central da imunidade humoral e as suas concentrações séricas são determinadas por rotina na prática clínica, pois fornecem informações importantes sobre o estado imunológico humoral. Num estudo prospetivo de centro único, avaliámos as concentrações séricas de IgA, IgE, IgG e IgM em doentes com apendicite aguda confirmada histologicamente (grupo de estudo, N=54) e comparámos com o grupo controle (N=69), doentes submetidos a apendicectomia, mas com achados histológicos normais, doentes submetidos a cirurgia de ambulatório e voluntários saudáveis. As concentrações séricas de imunoglobulinas foram normais em todos os casos, exceto para IgE, que estava elevada tanto no grupo estudo (20%) quanto no grupo controle (21%) (p= 0,609). Esses valores estão em boa concordância com a prevalência de alergias na população geral. O nosso estudo é o primeiro a abordar especificamente a resposta imune humoral de imunoglobulinas na apendicite aguda na literatura inglesa. Demonstrámos que a apendicite aguda não provoca uma resposta imune humoral específica.pt_PT
dc.description.abstractABSTRACT - Immunoglobulins are a central component of humoral immunity and their serum concentrations are routinely determined in clinical practice because they provide key information on the humoral immune status. In a single-center prospective design study, we evaluated IgA, IgE, IgG, and IgM serum concentrations in patients with histologic confirmed acute appendicitis (study group, N=54) and compared it to the control group (N=69), patients submitted to appendectomy, but with normal histological findings, patients submitted to day case surgery and healthy volunteers. "e serum concentrations of immunoglobulins were normal in all cases, except for IgE, that were elevated in both the study (20%) and control (21 %) groups (p= 0.609). These values are in good agreement with the prevalence of allergies in the general population. Our study is the first to address specifically the acute appendicitis Immunoglobulins humoral immune response in the English literature. We showed that acute appendicitis does not elicit a specific humoral immune response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarvalho N, Carolino E, Carvalho I, Lisboa V, Coelho H, Trindade M, et al. Immunoglobulin serum concentrations do not correlate with acute appendicitis. Rev Port Cir. 2022;(53):37-45.pt_PT
dc.identifier.doi10.34635/rpc.970pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15425
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Cirurgiapt_PT
dc.relation.publisherversionhttps://revista.spcir.com/index.php/spcir/article/view/970pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAcute appendicitispt_PT
dc.subjectHumoral immune responsept_PT
dc.subjectIgApt_PT
dc.subjectIgEpt_PT
dc.subjectIgGpt_PT
dc.subjectIgMpt_PT
dc.subjectApendicite agudapt_PT
dc.subjectResposta imune humoralpt_PT
dc.titleImmunoglobulin serum concentrations do not correlate with acute appendicitispt_PT
dc.title.alternativeAs concentrações séricas de imunoglobulina não se correlacionam com a apendicitept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage45pt_PT
oaire.citation.issue53pt_PT
oaire.citation.startPage37pt_PT
oaire.citation.titleRevista Portuguesa de Cirurgiapt_PT
person.familyNameCarolino
person.givenNameElisabete
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id25821697000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscovery77930d39-ed34-44dc-a4a6-9bf833e5e688

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Immunoglobulin serum concentrations do not correlate with acute appendicitis.pdf
Size:
336.92 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos