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Gut microbiota impact on Angolan children with sickle cell disease

2020-10Conference object Open access
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dc.contributor.authorBrito, Miguel
dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorGinete, Catarina
dc.contributor.authorMendes, Joana
dc.contributor.authorVasconcelos, J.
dc.contributor.authorSantos, Brígida
dc.date.accessioned2022-03-16T12:34:57Z
dc.date.available2022-03-16T12:34:57Z
dc.date.issued2020-10
dc.descriptionFCT/Aga Khan (project no. 330842553).pt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractIntroduction: Clinical manifestations of Sickle cell disease (SCD) are very heterogeneous, and the intestinal microbiome appears to be crucial in the modulation of inflammation, cell adhesion, and induction of aged neutrophils, which are the main interveners of recurrent vaso-occlusive crisis. Enterocyte injury, increased permeability, altered microbial composition, and bacterial overgrowth have all been documented as microbial and pathophysiologic changes in the gut microbiome of SCD patients in recent research studies. Microbiota analysis in SCD populations will be essential to demonstrate the importance of specific bacteria and their function in this disease and provide new insights for attenuating symptoms and new drug targets. Purpose: Given this, our aim is to sequence by NGS bacterial 16S RNA gene in order to characterize the gut microbiome of SCD children and healthy siblings, as a control.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBrito M, Delgadinho M, Ginete C, Mendes J, Vasconcelos J, Santos B. Gut microbiota impact on Angolan children with sickle cell disease. In: ASCAT 2020 – The 15th Annual Sickle Cell and Thalassaemia Conference [online], October 26-31, 2020.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14483
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFCT/Aga Khan (project no. 330842553)pt_PT
dc.relationFCT_UIDB/05608/2020pt_PT
dc.relationFCT_UIDP/05608/2020pt_PT
dc.relation.publisherversionhttps://web-eur.cvent.com/event/4c632bd1-0e87-4d69-a2b3-8d3bce1b08e4/summarypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectGut microbiomept_PT
dc.subjectChildrenpt_PT
dc.subjectAngolapt_PT
dc.subjectFCT_Aga Khan (project no. 330842553)pt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleGut microbiota impact on Angolan children with sickle cell diseasept_PT
dc.typeconference object
dspace.entity.typePublication
person.familyNameBrito
person.familyNameNeves Delgadinho
person.familyNameHonrado Ginete
person.givenNameMiguel
person.givenNameMariana Isabel
person.givenNameAna Catarina
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0002-2334-782X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublicationca55aab6-9a58-4f79-ab79-20513414099f
relation.isAuthorOfPublicationdfb2fbba-17ff-42fb-905a-fcfc8f326e1c
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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