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Assessment of out-of-field doses in radiotherapy treatments of paediatric patients using Monte Carlo methods and measurements

2020-03Journal article Restricted access
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dc.contributor.authorSá, Ana Cravo
dc.contributor.authorBarateiro, Andreia
dc.contributor.authorBednarz, Bryan
dc.contributor.authorBorges, Cecília
dc.contributor.authorPereira, Joana
dc.contributor.authorBaptista, Mariana
dc.contributor.authorPereira, Miguel
dc.contributor.authorZarza-Moreno, Miriam
dc.contributor.authorAlmeida, Pedro
dc.contributor.authorVaz, Pedro
dc.contributor.authorMadaleno, Tiago
dc.contributor.authorRomanets, Yuriy
dc.date.accessioned2020-03-25T16:50:01Z
dc.date.available2020-03-25T16:50:01Z
dc.date.issued2020-03
dc.description.abstractPurpose: To assess out-of-field doses in radiotherapy treatments of pediatric patients, using Monte Carlo methods to implement a new model of the linear accelerator validated against measurements and developing a voxelized anthropomorphic pediatric phantom. Methods: CT images of a physical anthropomorphic pediatric phantom were acquired and dosimetric planning using a TPS was obtained. The CT images were used to perform the voxelization of the physical phantom using the ImageJ software and later implemented in MCNP. In order to validate the Monte Carlo model, dose measurements of the 6 MV beam and Linac with 120 MLC were made in a clinical setting, using ionization chambers and a water phantom. afterward, TLD measurements in the physical anthropomorphic phantom were performed in order to assess the out-of-field doses in the eyes, thyroid, c-spine, heart, and lungs. Results: The Monte Carlo model was validated for in-field and out-of-field doses with average relative differences below 3%. The average relative differences between TLD measurements and Monte Carlo is 14,3% whilst the average relative difference between TLD and TPS is 55,8%. Moreover, organs up to 22.5 cm from PTV center show TLD and MCNP6 relative differences and TLD and TPS relative differences up to 21.2% and 92.0%, respectively. Conclusions: Our study provides a novel model that could be used in clinical research, namely in dose evaluation outside the treatment fields. This is particularly relevant, especially in pediatric patients, for studying new radiotherapy treatment techniques, since it can be used to estimate the development of secondary tumors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSá AC, Barateiro A, Bednarz B, Borges C, Pereira J, Baptista M, et al. Assessment of out-of-field doses in radiotherapy treatments of paediatric patients using Monte Carlo methods and measurements. Phys Med. 2020;71:53-64.pt_PT
dc.identifier.doi10.1016/j.ejmp.2020.02.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/11341
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1120179720300399?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectRadiotherapypt_PT
dc.subjectMonte Carlo methodpt_PT
dc.subjectOut-of-field dosespt_PT
dc.subjectClinical measurementpt_PT
dc.subjectAnthropomorphic paediatric phantompt_PT
dc.titleAssessment of out-of-field doses in radiotherapy treatments of paediatric patients using Monte Carlo methods and measurementspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage61pt_PT
oaire.citation.startPage53pt_PT
oaire.citation.titlePhysica Medicapt_PT
oaire.citation.volume71pt_PT
person.familyNameMorais Cravo de Sá
person.givenNameAna Maria
person.identifier.ciencia-id281E-62F9-4138
person.identifier.orcid0000-0002-1617-5193
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication945fd84c-3438-4df7-981c-9b70916ba612
relation.isAuthorOfPublication.latestForDiscovery945fd84c-3438-4df7-981c-9b70916ba612

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