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Authors
Advisor(s)
Abstract(s)
Desde dezembro de 2019, a doença de coronavírus 2019 (COVID-19), uma doença potencialmente fatal, está a conduzir rapidamente a uma crise de saúde pública em todo o mundo. Como sétimo género conhecido de coronavírus humano, o SARS-CoV-2 é comparável ao SARS-CoV e ao coronavírus da síndrome respiratória do Médio Oriente, pois todos causam pneumonia viral incomum. À medida que obtemos mais informações sobre a condição, a COVID-19 tem sido considerada mais como uma condição sistémica do que uma doença respiratória, especialmente em casos severos. Evidências crescentes têm revelado que as alterações plaquetárias estão associadas à gravidade da doença e ao aumento da mortalidade. Objetivou-se avaliar a variação da contagem de plaquetas e volume plaquetário médio (VPM) nos doentes com COVID-19, comparativamente aos seus valores anteriores à infeção. Amostras de sangue venoso foram obtidas a partir da população que frequenta os serviços de colheita de um laboratório privado em Lisboa, com acesso aos resultados mediante o consentimento informado. Os dados obtidos foram analisados com recurso ao Statistical Package for the Social Sciences (SPSS®), versão 27.0, através da análise estatística descritiva e dos testes paramétricos, nomeadamente o teste de t-student para amostras emparelhadas. Os resultados demonstraram que apesar da média dos valores da contagem de plaquetas terem sofrido uma diminuição e VPM um aumento após infeção por COVID19, a relação entre as variáveis não foi estatisticamente significativa. Não obstante, mais estudos com amostras maiores devem ser realizados antes da translação dos resultados para abordagens terapêuticas.
ABSTRACT - Since December 2019, coronavirus disease 2019 (COVID-19), a potentially fatal disease, has swiftly led to a public health crisis worldwide. As the seventh known human coronavirus genus, SARS-CoV-2 is comparable to SARS-CoV and Middle East respiratory syndrome coronavirus in that they all cause unusual viral pneumonia. As we gain further insights into the condition, COVID-19 is more a systemic condition than it is a respiratory disease, especially in severe cases. Mounting evidence has revealed that platelet changes are associated with disease severity and increased mortality. The aim was to assess the variation in platelet count and mean platelet volume (MPV) in COVID-19 patients compared to their pre-infection values. Venous blood samples were obtained from the population that attends the services of a private laboratory in Lisbon, with access to the results through informed consent. The data obtained will be analyzed using the Statistical Package for the Social Sciences (SPSS®), version 27.0, through descriptive statistical and parametric tests, namely the t-student test for paired samples. The results demonstrated that despite the mean platelet count values having decreased and MPV increased after COVID-19 infection, the relationship between the variables was not statistically significant. However, further studies with greater sample sizes should take place before the translation of the results into clinically relevant strategies.
ABSTRACT - Since December 2019, coronavirus disease 2019 (COVID-19), a potentially fatal disease, has swiftly led to a public health crisis worldwide. As the seventh known human coronavirus genus, SARS-CoV-2 is comparable to SARS-CoV and Middle East respiratory syndrome coronavirus in that they all cause unusual viral pneumonia. As we gain further insights into the condition, COVID-19 is more a systemic condition than it is a respiratory disease, especially in severe cases. Mounting evidence has revealed that platelet changes are associated with disease severity and increased mortality. The aim was to assess the variation in platelet count and mean platelet volume (MPV) in COVID-19 patients compared to their pre-infection values. Venous blood samples were obtained from the population that attends the services of a private laboratory in Lisbon, with access to the results through informed consent. The data obtained will be analyzed using the Statistical Package for the Social Sciences (SPSS®), version 27.0, through descriptive statistical and parametric tests, namely the t-student test for paired samples. The results demonstrated that despite the mean platelet count values having decreased and MPV increased after COVID-19 infection, the relationship between the variables was not statistically significant. However, further studies with greater sample sizes should take place before the translation of the results into clinically relevant strategies.
Description
Mestrado em Tecnologias Clínico-Laboratoriais
Keywords
COVID-19 SARS-CoV-2 Plaquetas Volume plaquetário médio Coagulopatia Platelets Mean platelet volume Coagulopathy
Citation
Ye J. Estudo do perfil plaquetário em doentes com COVID-19 [dissertation]. Lisboa: Escola Superior de Tecnologia da Saúde de Lisboa/Instituto Politécnico de Lisboa; 2023.
Publisher
Instituto Politécnico de Lisboa, Escola Superior de Tecnologia da Saúde de Lisboa