Repository logo
 
Publication

GDF-9 and BMP-15 direct the follicle symphony

2018-10Journal article Open access
Simple item page
dc.contributor.authorSanfins, Alexandra
dc.contributor.authorRodrigues, Patricia
dc.contributor.authorAlbertini, David F.
dc.date.accessioned2018-09-21T11:24:47Z
dc.date.available2018-09-21T11:24:47Z
dc.date.issued2018-10
dc.description.abstractUnderstanding the physiology underlying the complex dialog between the oocyte and it's surrounding somatic cells within the ovarian follicle has been crucial in defining optimal procedures for the development of clinical approaches in ART for women suffering from infertility and ovarian dysfunction. Recent studies have implicated oocyte-secreted factors like growth differentiation factor 9 (GDF-9) and bone morphogenetic protein 15 (BMP-15), members of the transforming growth factor-beta (TGFβ) superfamily, as potent regulators of folliculogenesis and ovulation. These two factors act as biologically active heterodimers or as homodimers in synergistic cooperation. Through autocrine and paracrine mechanisms, the GDF-9 and BMP-15 system have been shown to regulate growth, differentiation, and function of granulosa and thecal cells during follicular development playing a vital role in oocyte development, ovulation, fertilization, and embryonic competence. The present mini-review provides an overview of recent findings relating GDF-9 and BMP-15 as fundamental factors implicated in the regulation of ovarian function and discusses they're potential role as markers of oocyte quality in women.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSanfins A, Rodrigues P, Albertini DF. GDF-9 and BMP-15 direct the follicle symphony. J Assist Reprod Genet. 2018;35(10):1741-50.pt_PT
dc.identifier.doi10.1007/s10815-018-1268-4pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/8876
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007%2Fs10815-018-1268-4pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBMP-15pt_PT
dc.subjectFolliculogenesispt_PT
dc.subjectGDF-9pt_PT
dc.subjectOocyte qualitypt_PT
dc.subjectOvarian functionpt_PT
dc.subjectTGFβpt_PT
dc.titleGDF-9 and BMP-15 direct the follicle symphonypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1750
oaire.citation.issue10
oaire.citation.startPage1741
oaire.citation.titleJournal of Assisted Reproduction and Geneticspt_PT
oaire.citation.volume35
person.familyNameSanfins
person.familyNameRodrigues
person.givenNameAlexandra
person.givenNamePatricia
person.identifier1099069
person.identifier.ciencia-id9016-F4BA-4BF3
person.identifier.ciencia-idAF13-4A3B-F91C
person.identifier.orcid0000-0002-0740-1574
person.identifier.orcid0000-0001-7031-9939
person.identifier.ridD-1724-2018
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb17680fd-259a-483c-89cb-cc438e2068e7
relation.isAuthorOfPublicationb25e3f44-e9dc-4295-91b2-c65d684ab141
relation.isAuthorOfPublication.latestForDiscoveryb17680fd-259a-483c-89cb-cc438e2068e7

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
GDF-9 and BMP-15 direct the follicle symphony.pdf
Size:
1.31 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos