Repository logo
 
Publication

Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease

2009-09Journal article Open access
Simple item page
dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorFerreira, Paula
dc.contributor.authorTavares, Lourdes
dc.contributor.authorSantos, Paula Moura dos
dc.contributor.authorNeves, Manuela
dc.contributor.authorBrito, Miguel
dc.contributor.authorCravo, Marília
dc.date.accessioned2014-01-02T16:18:25Z
dc.date.available2014-01-02T16:18:25Z
dc.date.issued2009-09
dc.description.abstractObjectives - The aim of this work was to study the interaction between genetic polymorphisms (single-nucleotide polymorphisms, SNPs) of pro- and anti-inflammatory cytokines and fat intake on the risk of developing Crohn's disease (CD) or modifying disease activity. Methods - Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116 controls and 99 patients with CD. The type of fat intake was evaluated, and the interaction between SNPs and dietary fat in modulating disease activity was analyzed. Results - Individuals who were homozygous for the IL6-174G/C polymorphism had a six-fold higher risk for CD (odds ratio (OR)=6.1; 95% confidence interval (95% CI)=1.9-19.4), whereas the TT genotype on the TNFalpha-857C/T polymorphism was associated with more active disease (OR=10.4; 95% CI=1.1-94.1). A high intake of total, saturated, and monounsaturated fats, as well as a higher ratio of n-6/n-3 polyunsaturated fatty acid (PUFA), was associated with a more active phenotype (P<0.05). Furthermore, there was an interaction between dietary fat intake and SNPs, with a high intake of saturated and monounsaturated fats being associated with active disease, mainly in patients carrying the variant alleles of the 857 TNFalpha polymorphism (OR=6.0, 95% CI=1.4-26.2; OR=5.17; 95% CI=1.4-19.2, respectively) and the 174 IL6 polymorphism (OR=2.95; 95% CI=1.0-9.1; OR=3.21; 95% CI=1.0-10.4, respectively). Finally, low intake of n-3 PUFA and high n-6/n-3 PUFA ratio in patients with the TNFalpha 857 polymorphism were associated with higher disease activity (OR=3.6; 95% CI=1.0-13.0; OR=5.92; 95% CI=1.3-26.5, respectively). Conclusions - These results show that different types of fat may interact with cytokine genotype, modulating disease activity.por
dc.identifier.citationGuerreiro CS, Ferreira P, Tavares L, Santos PM, Neves M, Brito M, et al. Fatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's disease. Am J Gastroenterol. 2009;104(9):2241-9.por
dc.identifier.issn1572-0241
dc.identifier.urihttp://hdl.handle.net/10400.21/3052
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherNaturepor
dc.relation.publisherversionhttp://www.nature.com/ajg/journal/v104/n9/full/ajg2009313a.htmlpor
dc.subjectCrohn diseasepor
dc.subjectCytokinespor
dc.subjectDietary fatspor
dc.subjectFatty acidspor
dc.subjectGenetic predisposition to diseasepor
dc.subjectInterleukin-6por
dc.subjectNutrigenomicspor
dc.subjectPolymorphism, Single nucleotidepor
dc.subjectRisk factorpor
dc.subjectTumor necrosis factor-alphapor
dc.titleFatty acids, IL6, and TNFα polymorphisms: an example of nutrigenetics in Crohn's diseasepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2249por
oaire.citation.startPage2241por
oaire.citation.titleAmerican Journal of Gastroenterologypor
oaire.citation.volume104por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Fatty Acids, IL6, and TNFα polymorphisms.pdf
Size:
251.82 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos