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Blood pressure and its circadian pattern in obese and lean premenopausal women

2020-03Journal article Open access
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dc.contributor.authorSilva-Nunes, José
dc.contributor.authorBrito, Miguel
dc.contributor.authorVeiga, Luisa
dc.date.accessioned2020-04-27T18:20:04Z
dc.date.available2020-04-27T18:20:04Z
dc.date.issued2020-03
dc.description.abstractBackground: Obesity is frequently referred to as an independent risk factor for high blood pressure and hypertension is very prevalent among obese people. The aims of this study were: to compare office-based and 24 h blood pressure (BP) and its circadian pattern between lean and obese women; to study correlations between BP, insulin resistance (IR), and markers of subclinical inflammation/early atherosclerosis. Material and methods: Eighty-eight lean and 107 otherwise healthy obese women were characterized for anthropometrics, BP (office-based determinations and 24 h ABPM), and for glucose, insulin, triglycerides, interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-a), high-sensitivity C reactive protein (hs-CRP), retinol-binding protein 4 (RBP-4), leptin, adiponectin, resistin, monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), and vascular-cellular adhesion molecule 1 (VCAM-1). Insulin resistance was determined by homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and McAuley indexes (also Matsuda in obese). Results: The obese group presented higher office-based systolic/diastolic BP, systolic ambulatory blood pressure monitoring (ABPM), and more non-dippers. HOMA-IR and body fat was correlated to systolic (r2 = 0.176) and glucose to diastolic (p = 0.008; r = 0.256) ABPM. Age, QUICKI, and TNF-a was correlated with dipping (r2 = 0.172); adiponectin, age, BMI, and glucose to systolic (r2 = 0.226) and diastolic (r2 = 0.215) office-based BP. Concerning lean women, MCP-1 was associated with diastolic ABPM (p = 0.013; r = 0.267). Systolic office-based BP was associated with waist-to-hip ratio (p = 0.01; r = 0.273); this and RBP-4 was correlated with office-based diastolic BP (r2 = 0.12). Conclusion: Although relatively healthy, obese women present higher BP than lean. Anthropometrics, IR, and fasting glucose all influence BP in obesity; additionally, IR is involved in non-dipping. No strong correlation exists between BP/dipping and subclinical inflammation in either group of women.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva-Nunes J, Brito M, Veiga L. Blood pressure and its circadian pattern in obese and lean premenopausal women. Arterial Hypertens. 2020;24(1):30-7.pt_PT
dc.identifier.doi10.5603/AH.a2020.0005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/11535
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherVia Medicapt_PT
dc.relation.publisherversionhttps://journals.viamedica.pl/arterial_hypertension/article/view/67688pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectObesitypt_PT
dc.subjectHypertensionpt_PT
dc.subjectCardiovascular diseasept_PT
dc.subjectDippingpt_PT
dc.subjectSubclinical inflammationpt_PT
dc.subjectPremenopausept_PT
dc.subjectWomenpt_PT
dc.titleBlood pressure and its circadian pattern in obese and lean premenopausal womenpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage37pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage30pt_PT
oaire.citation.titleArterial Hypertensionpt_PT
oaire.citation.volume24pt_PT
person.familyNameBrito
person.familyNameVeiga
person.givenNameMiguel
person.givenNameLuisa
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0003-1153-8343
person.identifier.ridA-7970-2016
person.identifier.ridL-2730-2013
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id8318978600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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