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Higher mineralized bone volume is associated with a lower plain X-Ray vascular calcification score in hemodialysis patients

2017-07-07Journal article Restricted access
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dc.contributor.authorAdragao, Teresa
dc.contributor.authorFerreira, Anibal
dc.contributor.authorFrazão, João
dc.contributor.authorPapoila, Ana Luisa
dc.contributor.authorPinto, Iola
dc.contributor.authorMonier-Faugere, Marie-Claude
dc.contributor.authorMalluche, Hartmut H.
dc.date.accessioned2017-11-27T11:10:24Z
dc.date.available2017-11-27T11:10:24Z
dc.date.issued2017-07-07
dc.description.abstractBackground and objectives In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. Design, setting, participants and measurements In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). Results SVCS >= 3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS >= 3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95% CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS >= 3 (p = 0.015). An Agatston score> 400 was observed in 80% of the patients with a SVCS >= 3 versus 4% of patients with a SVCS<3, (p<0.001). Conclusion Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationADRAGAO, Teresa [et al] - Higher mineralized bone volume is associated with a lower plain X-Ray vascular calcification score in hemodialysis patients. Plos One. ISSN 1932-6203. Vol. 12, N.º 7 (2017), pp. 1-14pt_PT
dc.identifier.doi10.1371/journal.pone.0179868pt_PT
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.21/7587
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.subjectStage Renal-Diseasept_PT
dc.subjectCoronary-Artery Calcificationpt_PT
dc.subjectCardiovascular Riskpt_PT
dc.subjectCalciumpt_PT
dc.subjectDialysispt_PT
dc.subjectOsteodystrophypt_PT
dc.subjectMortalitypt_PT
dc.subjectStiffnesspt_PT
dc.subjectHistomorphometrypt_PT
dc.subjectProgressionpt_PT
dc.titleHigher mineralized bone volume is associated with a lower plain X-Ray vascular calcification score in hemodialysis patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume12pt_PT
person.familyNameFrazão
person.familyNamePapoila
person.familyNamePinto
person.familyNameMonier-Faugere
person.givenNameJoão
person.givenNameAna Luisa
person.givenNameIola
person.givenNameMarie-Claude
person.identifierR-000-ME5
person.identifier.ciencia-idA61B-5E51-0E42
person.identifier.ciencia-id251C-0273-1068
person.identifier.ciencia-id5715-2B2D-9ADC
person.identifier.orcid0000-0003-4497-5734
person.identifier.orcid0000-0002-2918-8364
person.identifier.orcid0000-0002-2945-1441
person.identifier.orcid0000-0002-5831-4681
person.identifier.ridS-2515-2016
person.identifier.scopus-author-id6507532321
person.identifier.scopus-author-id34969436900
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication287e5ccb-e43a-42c7-a632-df8b2b0fd985
relation.isAuthorOfPublication137d7dcc-401e-4d4a-862f-1d955c6f7257
relation.isAuthorOfPublication47b0fba8-db59-4f4b-af6e-2f120d693ef5
relation.isAuthorOfPublication.latestForDiscovery4b7ae9c9-ed08-43b9-8843-eeba989a2857

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