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The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to γδ T-cell cytotoxicity

2010-03Journal article Open access
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dc.contributor.authorLança, Telma
dc.contributor.authorCorreia, Daniel V.
dc.contributor.authorMoita, Catarina F.
dc.contributor.authorRaquel, Helena
dc.contributor.authorNeves-Costa, Ana
dc.contributor.authorFerreira, Cristina
dc.contributor.authorRamalho, José S.
dc.contributor.authorBarata, João T.
dc.contributor.authorMoita, Luís F.
dc.contributor.authorGomes, Anita Q.
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2020-08-26T15:40:10Z
dc.date.available2020-08-26T15:40:10Z
dc.date.issued2010-03
dc.description.abstractOn the path to successful immunotherapy of hematopoietic tumors, gamma-delta T cells offer great promise because of their human leukocyte antigen (HLA)-unrestricted targeting of a wide variety of leukemias/lymphomas. However, the molecular mechanisms underlying lymphoma recognition by gamma-delta T cells remain unclear. Here we show that the expression levels of UL16-binding protein 1 (ULBP1) determine lymphoma susceptibility to gamma-delta T cell-mediated cytolysis. Consistent with this, blockade of NKG2D, the receptor for ULBP1 expressed on all Vgamma9(+) T cells, significantly inhibits lymphoma cell killing. Specific loss-of-function studies demonstrate that the role of ULBP1 is nonredundant, highlighting a thus far unique physiologic relevance for tumor recognition by gamma-delta T cells. Importantly, we observed a very wide spectrum of ULBP1 expression levels in primary biopsies obtained from lymphoma and leukemia patients. We suggest this will impact on the responsiveness to gamma-delta T cell-based immunotherapy, and therefore propose ULBP1 to be used as a leukemia/lymphoma biomarker in upcoming clinical trials.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLanca T, Correia DV, Moita CF, Raquel H, Neves-Costa A, Gomes AQ, et al. The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to γδ T-cell cytotoxicity. Blood. 2010;115(12):2407-11.pt_PT
dc.identifier.doi10.1182/blood-2009-08-237123pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12197
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society of Hematologypt_PT
dc.relation.publisherversionhttps://ashpublications.org/blood/article/115/12/2407/125889/The-MHC-class-Ib-protein-ULBP1-is-a-nonredundantpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBiomarkers, Tumorpt_PT
dc.subjectBiopsypt_PT
dc.subjectCell line, Tumorpt_PT
dc.subjectClinical trials as topicpt_PT
dc.subjectGPI-Linked Proteinspt_PT
dc.subjectHumanspt_PT
dc.subjectImmunotherapypt_PT
dc.subjectIntracellular signaling peptides and proteinspt_PT
dc.subjectLeukemia, B-cellpt_PT
dc.subjectLeukemia, T-cellpt_PT
dc.subjectLymphomapt_PT
dc.subjectMembrane proteinspt_PT
dc.subjectPrecursor cell lymphoblastic leukemia-lymphomapt_PT
dc.subjectRNA, Small interferingpt_PT
dc.subjectReceptors, Antigenpt_PT
dc.subjectT-Lymphocytes, Cytotoxicpt_PT
dc.subjectT-cellpt_PT
dc.subjectGamma-deltapt_PT
dc.titleThe MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to γδ T-cell cytotoxicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2411pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2407pt_PT
oaire.citation.titleBloodpt_PT
oaire.citation.volume115pt_PT
person.familyNameGomes
person.givenNameAnita
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id7202386033
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875
relation.isAuthorOfPublication.latestForDiscovery2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875

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