Repository logo
 
Publication

Control of T cell effector functions by miRNAs

2018-07Journal article Restricted access
Simple item page
dc.contributor.authorInácio, Daniel P.
dc.contributor.authorAmado, Tiago
dc.contributor.authorSilva-Santos, Bruno
dc.contributor.authorGomes, Anita Quintal
dc.date.accessioned2018-09-21T09:52:18Z
dc.date.available2018-09-21T09:52:18Z
dc.date.issued2018-07
dc.description.abstractThe differentiation of effector T cells is a tightly regulated process that relies on the selective expression of lineage-defining master regulators that orchestrate unique transcriptional programs, including the production of distinct sets of effector cytokines. miRNAs are post-transcriptional regulators that are now viewed as critical players in these gene expression networks and help defining cell identity and function. This review summarises the role of individual miRNAs in the regulation of the differentiation of effector T cell subsets, including CD4+ T helper cells, cytotoxic CD8+ T cells and innate-like NKT cells. Moreover, we refer to miRNAs that have been identified to affect simultaneously two or more effector T cell populations, impacting on the balance between effector T cells in vivo, thus constituting potential biomarkers or targets for therapies aiming at boosting immunity or controlling autoimmunity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInácio DP, Amado T, Silva-Santos B, Gomes AQ. Control of T cell effector functions by miRNAs. Cancer Lett. 2018;427:63-73.pt_PT
dc.identifier.doi10.1016/j.canlet.2018.04.011pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/8873
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0304383518302726pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectmiRNAspt_PT
dc.subjectT cell differentiationpt_PT
dc.subjectEffector T cellspt_PT
dc.subjectT cell regulationpt_PT
dc.titleControl of T cell effector functions by miRNAspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage73pt_PT
oaire.citation.startPage63pt_PT
oaire.citation.titleCancer Letterspt_PT
oaire.citation.volume427pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Control of T cell effector functions by miRNAs.pdf
Size:
939.41 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos