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Hemin ameliorates the inflammatory activity in the inflammatory bowel disease: a non-clinical study in rodents

2022-08Journal article Open access
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dc.contributor.authorSilva, Inês
dc.contributor.authorCorreia, Rita
dc.contributor.authorPinto, Rui
dc.contributor.authorMateus, Vanessa
dc.date.accessioned2022-08-29T10:50:42Z
dc.date.available2022-08-29T10:50:42Z
dc.date.issued2022-08
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractBackground: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Currently, there is no cure, and pharmacological treatment aims to induce and maintain remission in patients, so it is essential to investigate new possible treatments. Hemin is a heme-oxygenase inducer that can confer anti-inflammatory, cytoprotective, and antiapoptotic effects; therefore, it can be considered an asset for different gastrointestinal pathologies, namely for IBD. Aim: This experiment aims to evaluate the efficacy and safety of hemin, in a chronic 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model in rodents. Methods: The induction of chronic colitis consisted of five weekly intrarectal administrations of 1% TNBS. Then, the mice were treated daily with 5 mg/kg/day or 10 mg/kg/day of hemin, through intraperitoneal injections, for 14 days. Results: Hemin demonstrated an anti-inflammatory effect through the reduction in tumor necrosis factor (TNF)-α levels, fecal calprotectin, and fecal hemoglobin. It was also found to be safe in terms of extraintestinal manifestations since hemin did not promote renal and/or hepatic changes. Conclusions: Hemin could become an interesting tool for new possible pharmacological approaches in the management of IBD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva I, Correia R, Pinto R, Mateus V. Hemin ameliorates the inflammatory activity in the inflammatory bowel disease: a non-clinical study in rodents. Biomedicines. 2022;10(8):2025.pt_PT
dc.identifier.doi10.3390/biomedicines10082025pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14942
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/10/8/2025pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectTNBS-induced colitispt_PT
dc.subjectAnti-inflammatory effectpt_PT
dc.subjectExperimental colitispt_PT
dc.subjectHeme-oxygenase inducerpt_PT
dc.subjectHeminpt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleHemin ameliorates the inflammatory activity in the inflammatory bowel disease: a non-clinical study in rodentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.startPage2025pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume10pt_PT
person.familyNameda Silva
person.familyNamePinho Mateus
person.givenNameInês Filipa Janeiro da Silva
person.givenNameVanessa Alexandra
person.identifier.ciencia-idC010-323F-3266
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0001-7049-2512
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

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