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Implementation of a new reference values database for semiquantification in123I-FP-CIT brain single emission tomography

2015-10Conference object Open access
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dc.contributor.authorQueiroga, Margarida
dc.contributor.authorSilva, Diana
dc.contributor.authorElias, Madalena
dc.contributor.authorSerrano, José
dc.contributor.authorMadrid, José
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorSousa, Eva
dc.date.accessioned2015-11-04T11:08:54Z
dc.date.available2015-11-04T11:08:54Z
dc.date.issued2015-10
dc.description.abstractBrain dopamine transporters imaging by Single Emission Tomography (SPECT) with 123I-FP-CIT (DaTScanTM) has become an important tool in the diagnosis and evaluation of Parkinson syndromes.This diagnostic method allows the visualization of a portion of the striatum – where healthy pattern resemble two symmetric commas - allowing the evaluation of dopamine presynaptic system, in which dopamine transporters are responsible for dopamine release into the synaptic cleft, and their reabsorption into the nigrostriatal nerve terminals, in order to be stored or degraded. In daily practice for assessment of DaTScan TM, it is common to rely only on visual assessment for diagnosis. However, this process is complex and subjective as it depends on the observer’s experience and it is associated with high variability intra and inter observer. Studies have shown that semiquantification can improve the diagnosis of Parkinson syndromes. For semiquantification, analysis methods of image segmentation using regions of interest (ROI) are necessary. ROIs are drawn, in specific - striatum - and in nonspecific – background – uptake areas. Subsequently, specific binding ratios are calculated. Low adherence of semiquantification for diagnosis of Parkinson syndromes is related, not only with the associated time spent, but also with the need of an adapted database of reference values for the population concerned, as well as, the examination of each service protocol. Studies have concluded, that this process increases the reproducibility of semiquantification. The aim of this investigation was to create and validate a database of healthy controls for Dopamine transporters with DaTScanTM named DBRV. The created database has been adapted to the Nuclear Medicine Department’s protocol, and the population of Infanta Cristina’s Hospital located in Badajoz, Spain.pt_PT
dc.identifier.citationQueiroga M, Silva D, Elias M, Serrano J, Carolino E, Sousa E, et al. Implementation of a new reference values database for semiquantification in123I-FP-CIT brain single emission tomography. In EANM'15 – Annual Congress of the European Association of Nuclear Medicine, Hamburg (Germany), October 10-14, 2015.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/5339
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://eanm15.eanm.org/programme/docs/FINAL_EANM15_CTE_ABSTRACT_BOOK.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectNuclear medicinept_PT
dc.subjectReference values databasept_PT
dc.subjectBrain single emission tomographypt_PT
dc.subjectSPECTpt_PT
dc.subject123I-FP-CITpt_PT
dc.subjectParkinson diseasept_PT
dc.subjectSpainpt_PT
dc.titleImplementation of a new reference values database for semiquantification in123I-FP-CIT brain single emission tomographypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceHamburgopt_PT
person.familyNameCarolino
person.givenNameElisabete
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id25821697000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscovery77930d39-ed34-44dc-a4a6-9bf833e5e688

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