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Retinal structural changes in preterm children without retinopathy of prematurity

2021-04Journal article Restricted access
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dc.contributor.authorMaleita, Diogo
dc.contributor.authorSerras-Pereira, Rita
dc.contributor.authorPassos, Inês
dc.contributor.authorElisa-Luís, Maria
dc.contributor.authorAlves, Marta
dc.contributor.authorPapoila, Ana Luísa
dc.contributor.authorBrito, Cristina
dc.contributor.authorCunha, João Paulo
dc.contributor.authorFerreira, Joana Tavares
dc.date.accessioned2020-12-23T12:58:42Z
dc.date.available2020-12-23T12:58:42Z
dc.date.issued2021-04
dc.description.abstractPurpose: The aim of this study was to compare all retinal layers' thickness in full-term and preterm children without retinopathy of prematurity (ROP). Methods: Cross-sectional study including two groups of patients: group 1 children with a history of preterm gestation without ROP (gestational age < 37 weeks) and group 2 healthy children with a history of full-term gestation. All subjects underwent an ophthalmic examination including spectral domain-optical coherence tomography. After automatic retinal segmentation, each retinal layer thickness (eight separate layers and overall thickness) was calculated in all nine Early Treatment Diabetic Retinopathy Study areas. Demographic, systemic, gestational, and birth data were collected. Generalized additive regression models were used to analyze the data. Results: Fifty-one children (51 eyes) were recruited, 19 full-term and 32 preterm children, mean age at an ophthalmic examination of 10.58 (4.21) and 14.13 (3.16), respectively. In multivariable analysis, the preterm group's retinal thickness was significantly decreased in total retina nasal outer sector, ganglion cell layer (GCL), and inner plexiform layer (IPL), specifically GCL temporal outer (p = 0.010), GCL superior outer (p = 0.009), IPL temporal outer (p = 0.022), and IPL superior outer (p = 0.004), when compared with the full-term group. From the variables compared only with a birth head circumference that influenced the models, a non-linear association was identified and consequently modeled with splines through a generalized additive model. Conclusion: This study suggests that preterm children without ROP have structural retinal alterations, mostly in GCL and IPL in outer areas of the macula. Therefore, it is crucial to question gestational history since these retinal changes may be found later in life leading to a useless investigation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMaleita D, Serras-Pereira R, Passos I, Elisa-Luís M, Cunha JP, Ferreira JT, et al. Retinal structural changes in preterm children without retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2021;259(4):1025-33.pt_PT
dc.identifier.doi10.1007/s00417-020-04986-0pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12515
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00417-020-04986-0pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectGanglion cell layerpt_PT
dc.subjectInner plexiform layerpt_PT
dc.subjectOptical coherence tomographypt_PT
dc.subjectPreterm childrenpt_PT
dc.subjectRetinal layer thicknesspt_PT
dc.titleRetinal structural changes in preterm children without retinopathy of prematuritypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1033pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1025pt_PT
oaire.citation.titleGraefe's Archive for Clinical and Experimental Ophthalmologypt_PT
oaire.citation.volume259pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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