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Cross-regulation between cytokine and microRNA pathways in T cells

2015-06Journal article Restricted access
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dc.contributor.authorAmado, Tiago
dc.contributor.authorSchmolka, Nina
dc.contributor.authorMetwally, Hozaifa
dc.contributor.authorSilva-Santos, Bruno
dc.contributor.authorGomes, Anita Quintal
dc.date.accessioned2016-08-23T15:51:35Z
dc.date.available2016-08-23T15:51:35Z
dc.date.issued2015-06
dc.description.abstractmicroRNA (miRNA) mediated regulation of protein expression has emerged as an important mechanism in T-cell physiology, from development and survival to activation, proliferation, and differentiation. One of the major classes of proteins involved in these processes are cytokines, which are both key input signals and major products of T-cell function. Here, we summarize the current data on the molecular cross-talk between cytokines and miRNAs: how cytokines regulate miRNA expression, and how specific miRNAs control cytokine production in T cells. We also describe the inflammatory consequences of deregulating the miRNA/cytokine axis in mice and humans. We believe this topical area will have key implications for immune modulation and treatment of autoimmune pathology.pt_PT
dc.identifier.citationAmado T, Schmolka N, Metwally H, Silva-Santos B, Gomes AQ. Cross-regulation between cytokine and microRNA pathways in T cells. Eur J Immunol. 2015;45(6):1584-95.pt_PT
dc.identifier.doi10.1002/eji.201545487pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6399
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/eji.201545487/abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectCytokinespt_PT
dc.subjectHumanspt_PT
dc.subjectInflammationpt_PT
dc.subjectMicroRNAspt_PT
dc.subjectT-Lymphocytespt_PT
dc.subjectGene expression regulationpt_PT
dc.subjectSignal transductionpt_PT
dc.titleCross-regulation between cytokine and microRNA pathways in T cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1595pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1584pt_PT
oaire.citation.titleEuropean Journal of Immunologypt_PT
oaire.citation.volume45pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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