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Translation termination and protein folding pathway genes are not correlated in gastric cancer

2009-03Journal article Open access
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dc.contributor.authorMalta-Vacas, Joana
dc.contributor.authorNolasco, Sofia
dc.contributor.authorMonteiro, Carolino
dc.contributor.authorSoares, Helena
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-01-01T18:47:19Z
dc.date.available2014-01-01T18:47:19Z
dc.date.issued2009-03
dc.description.abstractBackground: The eukaryotic release factor 3 (eRF3) has been shown to affect both tubulin and actin cytoskeleton, suggesting a role in cytoskeleton assembly, mitotic spindle formation and chromosome segregation. Also, direct interactions between eRF3 and subunits of the cytosolic chaperonin CCT have been described. Moreover, both eRF3a and CCT subunits have been described to be up-regulated in cancer tissues. Our aim was to evaluate the hypothesis that eRF3 expression levels are correlated with the expression of genes encoding proteins involved in the tubulin folding pathways. Methods: Relative expression levels of eRF1, eRF3a/GSPT1, PFDN4, CCT2, CCT4, and TBCA genes in tumour samples relative to their adjacent normal tissues were investigated using real time-polymerase chain reaction in 20 gastric cancer patients. Results: The expression levels of eRF3a/GSPT1 were not correlated with the expression levels of the other genes studied. However, significant correlations were detected between the other genes, both within intestinal and diffuse type tumours. Conclusions: eRF3a/GSPT1 expression at the mRNA level is independent from both cell translation rates and from the expression of the genes involved in tubulin-folding pathways. The differences in the patterns of expression of the genes studied support the hypothesis of genetically independent pathways in the origin of intestinal and diffuse type gastric tumours.por
dc.identifier.citationMalta-Vacas J, Nolasco S, Monteiro C, Soares H, Brito M. Translation termination and protein folding pathway genes are not correlated in gastric cancer. Clin Chem Lab Med. 2009;47(4):427-31.por
dc.identifier.issn1434-6621
dc.identifier.urihttp://hdl.handle.net/10400.21/3044
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherDe Gruyterpor
dc.relation.publisherversionhttps://www.degruyter.com/view/j/cclm.2009.47.issue-4/cclm.2009.091/cclm.2009.091.xmlpor
dc.subjectGastric cancerpor
dc.subjectCCT subunitspor
dc.subjectProtein folding pathwayspor
dc.subjectTranslation terminationpor
dc.subjectGene expression regulationpor
dc.subjectProtein biosynthesispor
dc.subjectRNA, Messengerpor
dc.subjectStomach neoplasmspor
dc.titleTranslation termination and protein folding pathway genes are not correlated in gastric cancerpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage431por
oaire.citation.startPage427por
oaire.citation.titleClinical Chemistry and Laboratory Medicinepor
oaire.citation.volume47por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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