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Targeting gd T lymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical application

2010-12Journal article Open access
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dc.contributor.authorGomes, Anita Q.
dc.contributor.authorMartins, Duarte S.
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2020-08-26T15:16:03Z
dc.date.available2020-08-26T15:16:03Z
dc.date.issued2010-12
dc.description.abstractAbundant interferon-γ secretion, potent cytotoxicity, and major histocompatibility complex-independent targeting of a large spectrum of tumors make γδ T cells attractive mediators of cancer immunotherapy. However, a better understanding of the molecular mechanisms involved in tumor cell recognition and γδ T-cell activation is required to improve the limited success of γδ T-cell-mediated treatments. Here, we review key advances in basic knowledge made over the past 3 years and summarize the results of γδ T-cell-based clinical trials concluded to date. We also highlight new research directions on the basis of the modulation of receptors that control the function of γδ T cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes AQ, Martins DS, Silva-Santos B. Targeting gd T lymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical application. Cancer Res. 2010;70(24):10024-7.pt_PT
dc.identifier.doi10.1158/0008-5472.CAN-10-3236pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12195
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://cancerres.aacrjournals.org/content/70/24/10024pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHumanspt_PT
dc.subjectImmunotherapy, Adoptivept_PT
dc.subjectLymphocyte activationpt_PT
dc.subjectNeoplasmspt_PT
dc.subjectReceptors, Antigenpt_PT
dc.subjectT-Cellpt_PT
dc.subjectGamma-deltapt_PT
dc.subjectT-Lymphocyte subsetspt_PT
dc.titleTargeting gd T lymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical applicationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage10027pt_PT
oaire.citation.issue24pt_PT
oaire.citation.startPage10024pt_PT
oaire.citation.titleCancer Researchpt_PT
oaire.citation.volume70pt_PT
person.familyNameGomes
person.givenNameAnita
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id7202386033
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875
relation.isAuthorOfPublication.latestForDiscovery2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875

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