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Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice

2019-10Journal article Open access
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dc.contributor.authorRocha, João
dc.contributor.authorDireito, Rosa
dc.contributor.authorLima, Ana
dc.contributor.authorMota, Joana
dc.contributor.authorGonçalves, Margarida
dc.contributor.authorDuarte, Maria Paula
dc.contributor.authorSolas, João
dc.contributor.authorPeniche, Bruno Felício
dc.contributor.authorFernandes, Adelaide
dc.contributor.authorPinto, Rui
dc.contributor.authorFerreira, Ricardo Boavida
dc.contributor.authorSepodes, Bruno
dc.contributor.authorFigueira, Maria-Eduardo
dc.date.accessioned2019-11-21T13:37:49Z
dc.date.available2019-11-21T13:37:49Z
dc.date.issued2019-10
dc.descriptionFCT_UID/EMS/04077/2019pt_PT
dc.description.abstractPurpose - Little is known about the pharmacological effects of the phenolic compounds of Pennyroyal (Mentha pulegium). This Mediterranean aromatic plant, used as a gastronomic spice and as food preservative by the food industry has been studied mainly due to its essential oil antibacterial properties, composed primarily by monoterpenes. With this work, we aimed to evaluate the effects of a phenolic extract of pennyroyal in the impairment of inflammatory processes in Inflammatory Bowel Diseases (IBD) and in the potential inhibition of progression to colorectal cancer (CRC). Methods - To that purpose, we evaluated the effect of pennyroyal extract administration in a model of TNBS-induced colitis in mice and further determined its effect on human colon carcinoma cell proliferation and invasion. Results - The phenolic extract of pennyroyal exhibited antioxidant properties in vitro assays and administration of the extract in a rat model of carrageenan-induced paw edema led to significant anti-inflammatory effects. Further results evidenced a beneficial effect of the phenolic extract in the attenuation of experimental colitis and a potential antiproliferative effect on cultured colon cancer cells, effects not previously described, to our knowledge. A reduction in several markers of colon inflammation was observed following administration of the extract to colitis-induced mice, including functional and histological indicators. Successful inhibition of cancer cell invasion and proliferation was also observed in in vitro studies with HT-29 cells. Furthermore, the extract also led to a reduced expression of iNOS/COX-2 in the colon of colitis-induced mice, both being crucial mediators of intestinal inflammation. Conclusions - Taking into consideration the central role of inflammation in the pathophysiology of CRC and the recognized connection between inflammatory events and cancer, these results enlighten the relevance of the phenolic constituents of pennyroyal as important pharmacological sources in the investigation of new treatment options for patients with inflammatory bowel diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRocha J, Direito R, Lima A, Mota J, Gonçalves M, Solas J (João), et al. Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice. Biomed Pharmacother. 2019;118:109351.pt_PT
dc.identifier.doi10.1016/j.biopha.2019.109351pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/10733
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFCT_UID/EMS/04077/2019pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0753332219320128?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectColitispt_PT
dc.subjectInflammatory bowel diseasespt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectMentha pulegiumpt_PT
dc.subjectPennyroyalpt_PT
dc.subjectProliferationpt_PT
dc.subjectUID/EMS/04077/2019pt_PT
dc.titleReduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage109351pt_PT
oaire.citation.titleBiomedicine & Pharmacotherapypt_PT
oaire.citation.volume118pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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