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Effects of the interaction of tobacco smoke and alcohol consumption on buccal micronucleus in workers exposed occupationally to formaldehyde

2010-05Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorPrista, João
dc.contributor.authorGomes, Manuel C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2011-11-30T15:33:39Z
dc.date.available2011-11-30T15:33:39Z
dc.date.issued2010-05
dc.description.abstractOccupational exposure to formaldehyde (FA) has been shown to induce nasopharyngeal cancer and has been classified as carcinogenic to humans (group 1) on the basis of sufficient evidence in humans. Tobacco smoke has been associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco’s compounds. Alcohol is a recognized agent that influence cells in a genotoxic form, been citied as a strong agent with potential in the development of carcinogenic lesions. Epidemiological evidence points to a strong synergistic effect between cigarette smoking and alcohol consumption in the induction of cancers in the oral cavity. Approximately 90% of human cancers originate from epithelial cells. Therefore, it could be argued that oral epithelial cells represent a preferred target site for early genotoxic events induced by carcinogenic agents entering the body via inhalation and ingestion. The MN assay in buccal cells was also used to study cancerous and precancerous lesions and to monitor the effects of a number of chemopreventive agents.por
dc.identifier.citationLadeira C, Viegas S, Carolino E, Prista J, Gomes MC, Brito M. Effects of the interaction of tobacco smoke and alcohol consumption on buccal micronucleus in workers exposed occupationally to formaldehyde. Poster.por
dc.identifier.urihttp://hdl.handle.net/10400.21/758
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectAnatomia patológicapor
dc.subjectSaúde ocupacionalpor
dc.subjectFormaldeídopor
dc.subjectCancro nasofaríngeopor
dc.subjectConsumo de álcoolpor
dc.subjectTabagismopor
dc.titleEffects of the interaction of tobacco smoke and alcohol consumption on buccal micronucleus in workers exposed occupationally to formaldehydepor
dc.typeconference object
dspace.entity.typePublication
person.familyNameLadeira
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id1216-EFA3-1E0F
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person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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