Repository logo
 
Publication

Cytotoxicity of Aspergillus section Fumigati isolated from health care environments

2021-10Journal article Open access
Simple item page
dc.contributor.authorViegas, Carla
dc.contributor.authorTwarużek, Magdalena
dc.contributor.authorAlmeida, Beatriz
dc.contributor.authorDias, Marta
dc.contributor.authorRibeiro, Edna
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorSoszczyńska, Ewelina
dc.contributor.authorCaetano, Liliana Aranha
dc.date.accessioned2021-10-07T16:57:04Z
dc.date.available2021-10-07T16:57:04Z
dc.date.issued2021-10
dc.descriptionProject EXPOsE, nº 23222 (02/SAICT/2016)pt_PT
dc.descriptionProject IPL/2020/BIO-AmbuDrivers_ESTeSLpt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractThis study analyzed 57 Aspergillus section Fumigati (AF) isolates collected by active and passive sampling (N = 450) in several health care facilities and from a biological sampling of health care workers (N = 25) and controls (N = 22) in Portugal. All isolates were cultured in different media and screened for azole resistance. Cytotoxicity was assessed for 40 isolates in lung epithelial cells and kidney cells using the MTT assay. Aspergillus section Fumigati was prevalent in the health care facilities and in nasal swabs from health care workers and controls. All AF isolates reduced cell viability and presented medium to high cytotoxicity, with cytotoxicity being significantly higher in A549 lung epithelial cells. The cytotoxicity of isolates from the air and nasal swab samples suggested the inhalation route as a risk factor. Notably, 42% of AF isolates exhibited a pattern of reduced susceptibility to some of the most used antifungals available for the treatment of patients infected with these fungi. In sum, the epidemiology and clinical relevance of Aspergillus section Fumigati should continue to be addressed. A deeper understanding of the mechanisms underlying Aspergillus-mediated cytotoxicity is necessary.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationViegas C, Almeida B, Dias M, Ribeiro E, Carolino E, Caetano LA, et al. Cytotoxicity of Aspergillus section Fumigati isolated from health care environments. J Fungi. 2021;7(10):839.pt_PT
dc.identifier.doi10.3390/jof7100839pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13846
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationProject EXPOsE, nº 23222 (02/SAICT/2016)pt_PT
dc.relationProject IPL/2020/BIO-AmbuDrivers_ESTeSLpt_PT
dc.relationFCT_UIDB/05608/2020pt_PT
dc.relationFCT_UIDP/05608/2020pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2309-608X/7/10/839pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectAspergillus section Fumigatipt_PT
dc.subjectHealth care environmentpt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectLung epithelial cellspt_PT
dc.subjectProject EXPOsEpt_PT
dc.subjectProject nº 23222 (02/SAICT/2016)pt_PT
dc.subjectIPL/2020/BIO-AmbuDrivers_ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleCytotoxicity of Aspergillus section Fumigati isolated from health care environmentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue10pt_PT
oaire.citation.startPage839pt_PT
oaire.citation.titleJournal of Fungipt_PT
oaire.citation.volume7pt_PT
person.familyNameViegas
person.familyNameRibeiro
person.familyNameCarolino
person.familyNameAranha Caetano
person.givenNameCarla
person.givenNameEdna
person.givenNameElisabete
person.givenNameLiliana
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.orcid0000-0002-1545-6479
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0003-1496-2609
person.identifier.ridB-7217-2013
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id55443609700
person.identifier.scopus-author-id25821697000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication6517c656-f913-4f54-8682-77c2856c9e4c
relation.isAuthorOfPublication.latestForDiscoveryb5fa5da4-50c3-4b88-ae20-1bc63cb485f7

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Cytotoxicity of Aspergillus section Fumigati isolated from health care environments.pdf
Size:
494.19 KB
Format:
Adobe Portable Document Format
Download

Collections

ESTeSL - Artigos